Flora Vaccarino
Professor
Yale University
From this contributor
Promise and pitfalls of induced stem cells for autism
Induced pluripotent stem cells, which have the ability to become any cell type, including neurons, offer a powerful way to study neuropsychiatric disorders. But for this approach to reach its full potential, researchers must first address several challenges, such as variability between cell lines, say Flora Vaccarino and Jessica Mariani.

Promise and pitfalls of induced stem cells for autism
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Claims of necessity and sufficiency are not well suited for the study of complex systems
The earliest studies on necessary and sufficient neural populations were performed on simple invertebrate circuits. Does this logic still serve us as we tackle more sophisticated outputs?

Claims of necessity and sufficiency are not well suited for the study of complex systems
The earliest studies on necessary and sufficient neural populations were performed on simple invertebrate circuits. Does this logic still serve us as we tackle more sophisticated outputs?
Subthalamic plasticity helps mice squelch innate fear responses
When the animals learn that a perceived threat is not dangerous, long-term activity changes in a part of the subthalamus suppress their instinctive fears.

Subthalamic plasticity helps mice squelch innate fear responses
When the animals learn that a perceived threat is not dangerous, long-term activity changes in a part of the subthalamus suppress their instinctive fears.
To accelerate the study of neurodevelopment, we need a transdiagnostic framework
Our tendency to focus on one condition at a time likely silos expertise and services—and obscures critical connections across diagnostic categories.

To accelerate the study of neurodevelopment, we need a transdiagnostic framework
Our tendency to focus on one condition at a time likely silos expertise and services—and obscures critical connections across diagnostic categories.