Cerebellum

Recent articles

Research image of tau proteins in the brains of people with Alzheimer’s disease.

Supersized version of Alzheimer’s protein avoids clumping in brain

“Big tau” may explain why some brain regions, such as the cerebellum and brainstem, are largely spared from neurodegeneration, even though tau is expressed throughout the nervous system.

By Charles Q. Choi
16 August 2024 | 6 min read
Research image of neurons in the rostral anterior cingulate cortex (right, in green) sending signals to cells in the pontine nucleus (left, in yellow) to quell pain.

Cerebellar circuit may convert expected pain relief into real thing

The newly identified circuit taps into the brain’s opioid system to provide a top-down form of pain relief.

By Angie Voyles Askham
24 July 2024 | 6 min read
A slice of a cerebellum.

Mutation in top autism-linked gene may alter eye reflex

The discovery could help clinicians diagnose children who carry mutations in the gene, called SCN2A, and gauge their responses to potential therapies.

By Charles Q. Choi
26 February 2024 | 5 min read
An image of a fossil.

Expanding ‘little brain’ may have powered dinosaur flight

The cerebellum swelled in size before flight evolved among modern birds’ dinosaur ancestors, according to a new comparison of fossilized skulls and living birds.

By Annie Melchor
23 February 2024 | 5 min listen
Illustration of hybrid objects: part light bulb, part lab vial, some in blue and some in red to signify null and replicated results.

Null and Noteworthy: Busting biomarkers; going after GABA; reproducibility illusion

In this edition of Null and Noteworthy, scientists find little to be excited about in research on biomarkers for neurodevelopmental conditions.

By Laura Dattaro
16 February 2023 | 4 min read
Three-dimensional structure of cells in the cerebellum.

Flexible genomic architecture undergoes major redesigns during cerebellum development

A new atlas reveals how the structural shake-ups within a cell’s genome differ by cell type and brain region over time.

By Angie Voyles Askham
13 November 2022 | 4 min read
Illustration of hybrid objects: part light bulb, part lab vial, some in blue and some in red to signify null and replicated results.

Null and Noteworthy: Brain aging, oxytocin pathways, biomarker back-up

Null and replicated results in this month’s newsletter tackle aging, a purported pathway for oxytocin’s effects on autistic people, and a possible autism biomarker.

By Emily Harris
15 September 2022 | 5 min read

Mouse study links dopamine in cerebellum to social behavior

The signaling molecule’s social role in the ‘little brain’ involves Purkinje neurons in the Crus I and Crus II regions, a new study reveals.

By Sarah DeWeerdt
6 July 2022 | 5 min read
Illustration of hybrid objects: part light bulb, part lab vial, some in blue and some in red to signify null and replicated results.

Null and Noteworthy: INSAR keynote, typical cerebellums, social subdomains

In this edition, researchers sink a purported link between cerebellar volume and autism and buoy a theory about measuring social behaviors.

By Laura Dattaro
9 June 2022 | 4 min read
White lab mice bunched up in corner of cage.

Mouse models mirror cerebellum patterns seen in autism

Animals with different autism-linked mutations share disruptions to the mTOR signaling pathway, pointing to a potential molecular mechanism for the atypical cerebellar development seen in some autistic people.

By Angie Voyles Askham
12 May 2022 | 3 min read

Explore more from The Transmitter

Double-duty neurons in primary olfactory cortex pick up on more than just scent

The cells recognize not only odors, such as bananas and black licorice—but also images and words associated with those smells, according to single-neuron recordings from 17 people.

By Angie Voyles Askham
9 October 2024 | 7 min read

How neuroscience comics add KA-POW! to the field: Q&A with Kanaka Rajan

The artistic approach can help explain complex ideas frame by frame without diluting the science, Rajan says.

By Olivia Gieger
9 October 2024 | 7 min read

Former Columbia University psychiatrist committed research misconduct, says federal watchdog

Bret Rutherford, whose research was halted following a suicide in a clinical trial, falsely reported participant eligibility, according to the U.S. Office of Research Integrity.

By Brendan Borrell, Ellie Kincaid
8 October 2024 | 3 min read