Glial cells
Giant analysis reveals how autism-linked genes affect brain cell types
Genes that predispose people to autism account for a large portion of the neuronal and glial cell changes seen in those with the condition.
![Research illustration groups genes by their effects on brain cell types.](https://www.thetransmitter.org/wp-content/uploads/2024/06/fig-6a-1024x683.webp)
Giant analysis reveals how autism-linked genes affect brain cell types
Genes that predispose people to autism account for a large portion of the neuronal and glial cell changes seen in those with the condition.
Microglial overreaction to atypical neurons may drive autism
In mice and organoids lacking a neuronal protein, microglia prune synapses to excess.
![Research image of microglia in mice.](https://www.thetransmitter.org/wp-content/uploads/2023/12/1200-microglia-pruning-transmitter-neuroscience-1024x683.webp)
Microglial overreaction to atypical neurons may drive autism
In mice and organoids lacking a neuronal protein, microglia prune synapses to excess.
Grafted organoids reveal how microglia adapt to shifting brain environments
The chimeric mouse model could provide a more realistic way to study microglia’s roles in brain conditions such as autism.
Grafted organoids reveal how microglia adapt to shifting brain environments
The chimeric mouse model could provide a more realistic way to study microglia’s roles in brain conditions such as autism.
Mapping tool reveals microglia’s shape-shifting secrets
The approach could help test hypotheses about how atypical function of the brain’s immune cells contributes to autism.
![](https://www.thetransmitter.org/wp-content/uploads/2022/12/844-microglia-morphology.png)
Mapping tool reveals microglia’s shape-shifting secrets
The approach could help test hypotheses about how atypical function of the brain’s immune cells contributes to autism.
Multi-omics study captures CNTNAP2’s far-ranging effects
The in-depth approach shows mutations in the autism-linked gene disrupt neuronal growth and communication, as well as mitochondrial gene expression.
![lllustration of the junction between two nerve cells.](https://www.thetransmitter.org/wp-content/uploads/2022/12/844-final.jpg)
Multi-omics study captures CNTNAP2’s far-ranging effects
The in-depth approach shows mutations in the autism-linked gene disrupt neuronal growth and communication, as well as mitochondrial gene expression.
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New connectomes fly beyond the brain
Researchers are mapping the neurons in Drosophila’s ventral nerve cord, where the central nervous system meets the rest of the body.
![Research image of neurons in the fly’s ventral nerve cord.](https://www.thetransmitter.org/wp-content/uploads/2024/07/lede-motormodules-1200-1024x692.webp)
New connectomes fly beyond the brain
Researchers are mapping the neurons in Drosophila’s ventral nerve cord, where the central nervous system meets the rest of the body.
Building an autism research registry: Q&A with Tony Charman
A purpose-built database of participants who have shared genomic and behavioral data could give clinical trials a boost, Charman says.
![Illustration of researchers talking to laypeople amidst strands of DNA.](https://www.thetransmitter.org/wp-content/uploads/2024/07/1200_Charman-1024x687.webp)
Building an autism research registry: Q&A with Tony Charman
A purpose-built database of participants who have shared genomic and behavioral data could give clinical trials a boost, Charman says.
Cerebellar circuit may convert expected pain relief into real thing
The newly identified circuit taps into the brain’s opioid system to provide a top-down form of pain relief.
![](https://www.thetransmitter.org/wp-content/uploads/2024/07/paincircuit-1200-1024x692.webp)
Cerebellar circuit may convert expected pain relief into real thing
The newly identified circuit taps into the brain’s opioid system to provide a top-down form of pain relief.