Synaptic vesicles

lllustration of the junction between two nerve cells.
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Multi-omics study captures CNTNAP2’s far-ranging effects

The in-depth approach shows mutations in the autism-linked gene disrupt neuronal growth and communication, as well as mitochondrial gene expression.

By Charles Q. Choi
8 December 2022 | 4 min read
Oil and water with colors behind: blue, green, yellow and red.

How microscopic ‘condensates’ in cells might contribute to autism

A controversial idea about how cells compartmentalize their contents into droplets — like beads of oil in water — could be key to understanding autism, says Julie Forman-Kay.

By Angie Voyles Askham
23 February 2021 | 7 min read

New method exposes structures inside ‘rainbow’ of brain cells

Molecules from alpacas may enable scientists to identify cell types in the brain while also revealing their interior structures.

By Chloe Williams
4 January 2019 | 0 min watch

Dividing autism; novel messengers; million-dollar mark and more

A researcher proposes splitting autism into subtypes, mitochondria make neurotransmitters, and highly successful grantees may face a funding cap.

By Emily Willingham
11 May 2018 | 3 min read

New tool spotlights neuron junctions in living human brains

A new imaging technique allows researchers to illuminate the junctions between neurons in a living person’s brain.

By Rachel Zamzow
19 August 2016 | 2 min read

Rainbow of dyes maps neurons’ tangled paths in brain

A new method that lets researchers trace the paths of many neurons at once may reveal how neurons go astray in autism.

By Kate Yandell
13 May 2015 | 3 min read

Suite of methods yields complex model of neuronal junctions

Researchers debuted a three-dimensional model of an average synapse, the point of connection between neurons, in the 30 May issue of Science.

By Kate Yandell
2 July 2014 | 2 min read

Molecular mechanisms: Autism gene establishes brain links

The autism-linked protein MET is expressed at the junctions between neurons during early brain development in mice, suggesting that it helps establish the connections, according to a study published 21 June in The Journal of Comparative Neurology.

By Jessica Wright
27 August 2013 | 2 min read

Researchers watch as proteins travel to neuronal junctions

Using high-resolution microscopy, researchers can watch as signaling complexes assemble at neuronal junctions in zebrafish embryos, according to a study published 17 April in Cell Reports.

By Jessica Wright
8 May 2013 | 2 min read

Scientists home in on autism candidate gene’s role in brain

Four new studies of neuroligin-1 (NLGN1), a gene linked to autism, unravel its complex role in regulating the connections between neurons.

By Emily Singer
26 November 2012 | 6 min read

Explore more from The Transmitter

Research image of neurons in the fly’s ventral nerve cord.

New connectomes fly beyond the brain

Researchers are mapping the neurons in Drosophila’s ventral nerve cord, where the central nervous system meets the rest of the body.

By Laura Dattaro
26 July 2024 | 7 min read
Illustration of researchers talking to laypeople amidst strands of DNA.

Building an autism research registry: Q&A with Tony Charman

A purpose-built database of participants who have shared genomic and behavioral data could give clinical trials a boost, Charman says.

By Cathleen O’Grady
25 July 2024 | 8 min read

Cerebellar circuit may convert expected pain relief into real thing

The newly identified circuit taps into the brain’s opioid system to provide a top-down form of pain relief.

By Angie Voyles Askham
24 July 2024 | 6 min read