ASHG 2019

RNA, transcription

Antidote to ‘poison’ DNA may treat lethal form of epilepsy

An experimental drug silences a DNA segment and seems to prevent seizures and death in a condition related to autism.

By Nicholette Zeliadt
26 August 2020 | 3 min read

Brain ‘organoids’ point to new drug target for fragile X syndrome

New findings hint at why drugs that work in mouse models of fragile X syndrome have not been effective in people.

By Nicholette Zeliadt
18 October 2019 | 3 min read

Massive project doubles list of genes tied to autism

The largest analysis of sequences from autistic people and their families implicates 184 genes in the condition — nearly doubling the previous estimate.

By Nicholette Zeliadt
17 October 2019 | 3 min read

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Brain organoid size matches intensity of social problems in autistic people

Overgrown organoids could point to mechanisms underlying profound autism.

By Holly Barker
18 July 2024 | 5 min read

Persistent protein pairing enables memories to last

The complex of two memory proteins, rather than the individual molecules acting independently, underlie month-long memories in mice, a new study suggests.

By Elissa Welle
17 July 2024 | 5 min read
A digitally distorted image of a file folder against a blue gradient background.

Data access changes to UK Biobank stir unease in neuroscientists

“I feel a little bit in limbo,” says neuroscientist Stephanie Noble, who has paused a study using Biobank data after the repository shifted from a data download to a cloud-only access model.

By Calli McMurray
16 July 2024 | 7 min read