Single-Site Investigator-Initiated Clinical Trials (R61/R33 Clinical Trial Required | heart, lung, blood and sleep disorders | worldwide)

National Institutes of Health (NIH)

The Single-Site Investigator-Initiated Clinical Trials (R61/R33 Clinical Trial Required) funding from the National Institutes of Health (NIH) and the National Heart, Lung, and Blood Institute (NHLBI) supports applications to develop and conduct investigator-initiated single site clinical trials including efficacy, comparative effectiveness, pragmatic and/or dissemination and implementation science clinical trials. Applications are open to clinical research on cardiovascular, lung, blood and sleep disorders. Applications are open to researchers in the USA and worldwide.

The grant provides funding for up to 5 years.

Funding opportunity number: PAR-27-011

Applications close:

  • June 2, 2026
  • October 2, 2026
  • February 1, 2027
  • June 2, 2027
  • October 1, 2027
  • February 1, 2028
  • June 1, 2028
  • October 2, 2028