Gene expression
Recent articles
Polarized cortical organoids mimic the brain’s regional organization
The organoids show region-specific gene-expression changes that match those observed during fetal development.
Polarized cortical organoids mimic the brain’s regional organization
The organoids show region-specific gene-expression changes that match those observed during fetal development.
Nuclear location helps control gene activity during brain development
A study of developing human brain tissue suggests that genes switch on more strongly when they move from the nucleus’s edge toward structures that contain proteins involved in making and processing RNA.
Nuclear location helps control gene activity during brain development
A study of developing human brain tissue suggests that genes switch on more strongly when they move from the nucleus’s edge toward structures that contain proteins involved in making and processing RNA.
Loss of interneuron plasticity may be shared hallmark of neurodevelopmental conditions
Restoring an experience-dependent interneuron plasticity gene in adulthood improves memory and cuts seizures in CNTNAP2 knockout mice, a new study shows.
Loss of interneuron plasticity may be shared hallmark of neurodevelopmental conditions
Restoring an experience-dependent interneuron plasticity gene in adulthood improves memory and cuts seizures in CNTNAP2 knockout mice, a new study shows.
How thirteen-lined ground squirrels illuminate retinal development
In most mammalian retinas, rods outnumber cones. But that ratio is flipped in ground squirrels, a quirk that helps Seth Blackshaw explore how retinal cells develop their identities.
How thirteen-lined ground squirrels illuminate retinal development
In most mammalian retinas, rods outnumber cones. But that ratio is flipped in ground squirrels, a quirk that helps Seth Blackshaw explore how retinal cells develop their identities.
Cortical territories compete in developmental space race
Sensory and association regions are established through a reciprocal process, according to a new model of cortical development.
Cortical territories compete in developmental space race
Sensory and association regions are established through a reciprocal process, according to a new model of cortical development.
Diverse autism genes derail common developmental pathways
Multiple genetic mouse models initially show delayed cortical development, but the animals’ molecular trajectories diverge within weeks after birth, a new study finds.
Diverse autism genes derail common developmental pathways
Multiple genetic mouse models initially show delayed cortical development, but the animals’ molecular trajectories diverge within weeks after birth, a new study finds.
Cousin comparison parses genetic effects in autism
The approach helps reveal whether maternal genes contribute directly to autism in children or have indirect effects on the prenatal environment.
Cousin comparison parses genetic effects in autism
The approach helps reveal whether maternal genes contribute directly to autism in children or have indirect effects on the prenatal environment.
Maternity induces lasting gene-expression changes in mouse brains
The findings add to a small but growing body of research on neurological changes linked to pregnancy, birth and parenting.
Maternity induces lasting gene-expression changes in mouse brains
The findings add to a small but growing body of research on neurological changes linked to pregnancy, birth and parenting.
Brain’s blue spot possesses unexpected structure-function ties
The spatial arrangement of neurons in the locus coeruleus of mice corresponds with the cells’ targets across the brain, according to a new study.
Brain’s blue spot possesses unexpected structure-function ties
The spatial arrangement of neurons in the locus coeruleus of mice corresponds with the cells’ targets across the brain, according to a new study.
Gene activity in human cortex shows striking sex differences
The results mark a “dramatic shift” in how neuroscientists think about sex differences, and they may help explain sex biases in certain neurodegenerative and neurodevelopmental conditions.
Gene activity in human cortex shows striking sex differences
The results mark a “dramatic shift” in how neuroscientists think about sex differences, and they may help explain sex biases in certain neurodegenerative and neurodevelopmental conditions.
Explore more from The Transmitter
Grant review needs reform. How about we add an element of chance?
A process that uses a lottery system saves time, reduces strategic resubmission and accepts that, above a quality threshold, luck has always played a part in science funding.
Grant review needs reform. How about we add an element of chance?
A process that uses a lottery system saves time, reduces strategic resubmission and accepts that, above a quality threshold, luck has always played a part in science funding.
Fly neurons carry molecular signatures of their origins
The pattern of transcription factors a Drosophila neuron expresses offers clues to its lineage and birth order—and ultimately how neural circuits emerge.
Fly neurons carry molecular signatures of their origins
The pattern of transcription factors a Drosophila neuron expresses offers clues to its lineage and birth order—and ultimately how neural circuits emerge.
Prefrontal cortex has three transcriptomic acts across human lifespan, new atlas suggests
Various genes show distinct exits and entrances with age in the open-source dataset, the largest of its kind to date.
Prefrontal cortex has three transcriptomic acts across human lifespan, new atlas suggests
Various genes show distinct exits and entrances with age in the open-source dataset, the largest of its kind to date.