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Learn about early-career scientists starting their own labs.

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Interviews have been lightly edited for length and clarity.

March 2026

Francesca Mastrogiuseppe, research group leader, International School for Advanced Studies

Lab start date: October 2025

What do you study? What part of your research are you most excited about?

We aim to build mathematical models that help us understand how cortical neurons exchange and transform information. The brain’s hardware is extraordinarily complex: It is highly distributed, relying on millions of cells and intricately organized into recurrent loops of connectivity at both local and global scales. Understanding how behavior emerges from coordinated interactions within these networks by intuition alone, without the support of mathematical models, is extremely challenging. We therefore study simplified models and seek rigorous ways to link them to experimental data through close collaborations with experimental partners. Currently, one of our core research questions focuses on how the structure of mesoscopic cortical circuits, with their anatomical organization within and across areas, constrains and shapes how the brain learns and interacts with the world. Over the next few years, I am especially excited to investigate the mechanisms that link together the structure of anatomical projections to the structure of emergent tuning. Neural network models of cognitive tasks provide a natural starting point for this question.

Are there any traditions or practices from the labs you trained at that you will implement in your lab?

At both institutions where I trained, there was a tradition of giving departing lab members a book. Lab members would write handwritten dedications inside the books, and reading them now brings back vivid memories and reminds me of the wonderful people I met along the way. I plan to continue this tradition by giving a book to everyone who leaves the lab. I’ve started thinking about a title that reflects both our vision and the inspiring environment surrounding us.

What is the best advice you received from a mentor or colleague before opening your lab?

A mentor once warned me that one of the biggest mistakes a supervisor can make is assuming that younger scientists think and work the same way the supervisor once did. I try to listen carefully, observe closely and adapt the support I offer to the person in front of me. I have learned that trainees often provide unexpected answers and behave in surprising ways, and that—more often than not—this is both enriching and fun.

Anna Schroeder, assistant professor of systemic neuroscience, Ludwig Maximilian University Munich

Lab start date: April 2025

What do you study? What part of your research are you most excited about?

My lab studies how internal states—emotions, motivations and physiological needs—emerge from neural circuits and guide behavior. Focusing on the zona incerta as a key integrative hub, we use cutting-edge molecular, cellular and circuit-level technologies in behaving mice to dissect how this region shapes state-dependent actions. We are also investigating deep brain stimulation as a therapeutic approach to modulate these circuits in psychiatric disease. I am especially excited to see whether the circuit-level mechanistic insights we gain in the years ahead can refine existing neuromodulation therapies or inspire new applications. At the same time, we hope to build multiscale models that explain how coordinated neural activity reconfigures circuits to reprioritize goals, resolve competing drives and flexibly update actions as environments change.

Are there any traditions or practices from the labs you trained at that you will implement in your lab?

My Ph.D. supervisor held yearly two-way feedback sessions, which I plan to implement in my lab. We would each fill out a short form in advance—reflecting on ourselves and on each other—and then we would meet to talk it through. It was a great way to think about past goals and see how far we had come, while also having space to share concerns or dreams for the year ahead.

What is the best advice you received from a mentor or colleague before opening your lab?

One piece of advice I heard repeatedly from senior colleagues was that the biggest make-or-break factor in starting a lab is choosing the right team. Always meet candidates in person, trust your “gut feeling” and don’t overlook red flags. Your team will shape your lab’s culture and determine its success! It’s much better to wait than to hire the wrong person. I took this advice very much to heart when I started recruiting.

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