Liftoff: New lab alerts

Learn about early-career scientists starting their own labs.

Are you a new principal investigator? Email Francisco J. Rivera Rosario at [email protected]. Selected new labs may be featured in our Launch monthly newsletter.

Interviews have been lightly edited for length and clarity.

October 2025

Isabel Christie, principal investigator, University of Sheffield
Lab start date: October 2024

What do you study? What part of your research are you most excited about?

My lab studies oxygen homeostasis in the brain. Our research focuses on understanding how the brain ensures it receives adequate oxygen and how oxygen insufficiency contributes to age-related cognitive impairment. In the past, I have used MRI methods such as arterial spin labeling to study brain blood flow. For my future research, I am excited to start using hyperpolarized xenon. This is a gaseous MRI contrast agent that diffuses into the brain tissue a bit like oxygen. Hyperpolarized xenon is already used in human research, so there is a good chance of being able to translate my findings to humans. I am excited about working with physicists to probe how gas exchange in the brain might be characterized and measured.

What is the best advice you received from a mentor or colleague before opening your lab?

The best advice I received came from Harald Sontheimer at the University of Virginia. He said, “What happens when your experiment doesn’t work out? You do it again. What happens when your paper is rejected? You submit it again. The only reason you have made it this far is due to your persistence. From your track record, it’s clear you are not going to stop being persistent, so you are going to be fine.” You cannot argue with Harry’s logic. When you are feeling anxious, often logical thinking goes out the window. But I have never doubted my ability to be persistent, so this conversation helped me gain confidence.



Jacob Miller, assistant professor of psychology, University of Miami

Lab start date: January 2025

What do you study? What part of your research are you most excited about?

We are interested in how the architecture of the brain supports the remarkable array of higher-order cognition and human behaviors. For example, what brain circuits and processes support memory and cognitive control, and how are they implemented to enable flexible behavior? Why is the human brain limited in memory and processing capacity? And how do our short- and long-term memory systems interact with each other? I’m excited to extend the approaches and ideas of longitudinal, individualized experimental designs for human neuroimaging to a wider array of questions. How might memory representations and processes change not only across learning, but over long timescales of aging and cognitive decline?

Are there any traditions or practices from the labs you trained in that you will implement in your own lab?

I’m lucky to have had an amazing training and gained familiarity with a breadth of methods and topics. From this, I firmly believe that there is no “holy” method or level of analysis in neuroscience and psychology. The questions we are interested in dictate the techniques, methods and inferences we use—all with their own set of assumptions and drawbacks. Piecing these methods and approaches together with clever experiments is what will advance our knowledge base.

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