Optogenetics

Recent articles

Research image of green and purple mouse brain slices.

Putting a bright idea to the test

A surprising wave of findings in mice suggests that light and sound flickering at 40 hertz clears the brain of Alzheimer’s-disease-linked plaques. Several companies are hoping to prove it works in people.

By Shaena Montanari
21 August 2024 | 11 min read
Portrait of Kaspar Podgorski standing in his lab wearing a helmet with a climbing rope over his shoulder.

Climbing to new heights: Q&A with Kaspar Podgorski

The optical physiologist tracks neural computations inside the lab and scales sheer rock faces outside—even after a life-changing fall.

By Elissa Welle
21 June 2024 | 8 min read

Robots boost data consistency in rodent studies reliant on mechanical, optogenetic stimulation

Two new devices take experimenter variation out of the equation, the lead investigators say.

By Calli McMurray
15 May 2024 | 0 min watch
Photograph of Simone Biles vaulting at the Summer 2020 Olympics.

Learning or performance? Why the distinction matters for memory science

New methods make it possible to probe the neural substrates of memory with unprecedented precision. Making the most of them demands careful experimental design.

By Stephen Maren
11 March 2024 | 6 min read
Photograph of an intimidating lab mouse.

Newly found hypothalamus circuits shape bullying behaviors in mice

Activity in the tiny brain region helps submissive rodents learn to avoid aggressors, and aggressive mice to curb their attacks, according to two recent studies.

By Angie Voyles Askham
5 March 2024 | 6 min listen
A research image of a mouse brain under anesthesia

What goes up must come down: New marker flags decreased neural activity

Phosphorylation of the metabolic enzyme pyruvate dehydrogenase inversely correlates with neural activity, offering scientists a tool to study inhibition for the first time.

By Elissa Welle
14 February 2024 | 6 min read
Portrait of scientist Sheena Josselyn behind a window, with a reflection over her face.

Sheena Josselyn and memories lost, found and created

Her hunt for the engram opened a new avenue in memory research.

By Alla Katsnelson
30 January 2024 | 13 min read
A research image of a mouse brain

Immune-activation model mice escape infantile amnesia, retain early memories

Male pups born to mothers treated with immune-stimulating molecules show autism-like behaviors and, unlike wildtype animals, do not lose memories formed during early life.

By Giorgia Guglielmi
11 January 2024 | 5 min read
A brown mouse looks away from a white mouse in a cage to its left.

‘VIP’ interneurons may drive autism traits in Dravet syndrome

The inhibitory cells misfire and contribute to social difficulties in mice that model the syndrome.

By Lauren Schenkman
19 July 2023 | 6 min read
Figure shows cultured human kidney cells and cultured rat cortical neurons responding to light exposure.

Unconventional optogenetics technique spurs long-lasting changes in neuronal activity

Conventional optogenetic manipulations to excite or inhibit neurons stop when the light switches off. A new approach makes the changes last.

By Peter Hess
9 January 2023 | 4 min read

Explore more from The Transmitter

Illustration of an open journal featuring lines of text and small illustrations of eyes and mouths.

Sleep; noncoding regions of the genome; changing rates of U.S.-based autism diagnoses

Here is a roundup of autism-related news and research spotted around the web for the week of 4 November.

By Jill Adams
5 November 2024 | 2 min read
Illustration of a thermostat set to 22 point 5 degrees celsius, with a silhouette of a mouse adjusting its dial.

Mouse housing temperatures can cook experimental outcomes

Neuroscientists need to take note of how thermoregulatory processes influence the brain and behavior—for the sake of reproducibility and animal welfare.

By Caitlyn James, Elizabeth Repasky, Sandra Sexton
5 November 2024 | 5 min read
Photograph of two hands drawing overlapping red and blue waveforms on a chalkboard.

How to teach this paper: ‘Coordination of entorhinal-hippocampal ensemble activity during associative learning,’ by Igarashi et al. (2014)

Kei Igarashi and his colleagues established an important foundation in memory research: the premise that brain regions oscillate together to form synaptic connections and, ultimately, memories.

By Ashley Juavinett
4 November 2024 | 8 min read