Postsynaptic density

Recent articles

Pruning protein; cultural connection; cannabis consent and more

A pruning protein reshapes neurons, culture should be a consideration in trials of autism treatments, and another U.S. state adds autism to the list of indications for medical cannabis.

By Emily Willingham
8 December 2017 | 4 min read
Illustration of Protein factories at neuronal junctions

Protein factories at neuronal junctions take center stage in autism

Some genes linked to autism regulate the production of proteins at neuronal junctions, suggesting that disrupted protein synthesis contributes to the condition.

By Claudia Bagni, Fiona Hollis
12 September 2017 | 4 min read

Proteins that spark learning may play key part in autism

A new study ties autism risk to a core team of proteins that facilitate neuronal signaling as an animal learns.

By Ann Griswold
29 September 2016 | 3 min read

Cell skeleton breakdown may spur autism symptoms in mice

An autism-linked mutation in the SHANK3 gene alters the protein skeleton of mouse neurons. Repairing the scaffold eases the animals’ social deficits.

By Nicholette Zeliadt
15 June 2015 | 4 min read

Method isolates protein complexes from neuronal junctions

Researchers have for the first time isolated and characterized protein complexes found at the points of connection between neurons. Mutations in some of these proteins are linked to autism.

By Kate Yandell
17 December 2014 | 2 min read

Large study underscores role of gene copy number in autism

People with autism tend to carry mutations that duplicate or delete several genes at once, according to a large study published 1 May in the American Journal of Human Genetics.

By Jessica Wright
2 June 2014 | 5 min read

Brain atlas maps gene expression in three dimensions

Researchers have charted patterns of gene expression in a three-dimensional representation of the human brain. The results, published 20 September in Nature, show that different brain regions have distinct molecular and functional roles.

By Jessica Wright
14 November 2012 | 2 min read

Defects in autism risk genes may lead to slower signals

Mutations in two genes linked to autism, neurexin and neuroligin, slow down neuronal signaling, according to research published 2 August in Science. Analyzing the mutations in the nematode Caenorhabditis elegans, the study found that mutations in these genes affect signaling in the opposite direction than is typical.

By Emily Singer
6 August 2012 | 4 min read

Molecular mechanisms: Autism gene tied to neuronal junctions

Neurobeachin, or NBEA, an autism–associated gene, may regulate the transport of signaling molecules to neuronal branches, according to a study published 22 November in Nature Communications.

By Jessica Wright
24 January 2012 | 3 min read

Molecular mechanisms: SHANK2 mutants alter synapses

Three mutations in SHANK2, an autism-associated gene, each lead to abnormal synapses, the junctions between neurons, according to a study in Human Molecular Genetics.

By Jessica Wright
30 November 2011 | 3 min read

Explore more from The Transmitter

Illustration of a lab with a smoking crater in the middle of the floor.

A scientific fraud. An investigation. A lab in recovery.

Science is built on trust. What happens when someone destroys it?

By Calli McMurray
4 October 2024 | 26 min read
Illustration of hands sewing red and white threads in a DNA-like pattern into a blue-gray fabric.

Untangling biological threads from autism’s phenotypic patchwork reveals four core subtypes

People belonging to the same subtype share genetic variants, behaviors and often co-occurring diagnoses, according to a new preprint.

By Holly Barker
3 October 2024 | 5 min read
Illustration of a colorful, donut-shaped object resting on a distorted plane with its own topography.

Neural manifolds: Latest buzzword or pathway to understand the brain?

When you cut away the misconceptions, neural manifolds present a conceptually appropriate level at which systems neuroscientists can study the brain.

By Matthew Perich
2 October 2024 | 8 min read