News / Spectrum

X-chromosome genes; neurobiology of infant crying; MCHAT in preemies

Here is a roundup of autism-related news and research spotted around the web for the week of 2 September.

By Jill Adams

3 September 2024 | 2 min read

Mice missing the autism-linked gene PTEN in specific cortical regions display disrupted temporal processing of sound across development. Neurobiology of Disease
The X chromosome contains many genes associated with neurodevelopmental conditions in boys and girls—in the latter, such conditions result from X-chromosome silencing. Spectrum has previously covered the role that X-chromosome genes play in brain development. Current Opinion in Neurobiology
Deleting the autism-linked gene CHD8 in astrocytes, but not microglia, disrupts injury-triggered reactive gliosis. Cell Reports

Upregulation of two biochemical pathways known to contribute to autism alters mouse pup vocalization and synaptic connectivity, a finding that could illuminate the neurobiology involved in infant crying. Journal of Neuroscience
Mice missing the FMR1 gene, a model of fragile X syndrome, are hyposensitive to touch and show poor encoding of tactile stimuli in somatosensory neurons, according to a preprint. bioRxiv
The Modified Checklist for Autism in Toddlers (MCHAT) predicts an autism diagnosis in children born prematurely with good sensitivity and specificity, suggesting screening should not be delayed based on adjusted age. Developmental Medicine & Child Neurology
Linking genotypes with phenotypes in autism enables scientists to subtype the condition into classes that appear to be tied to the developmental timing of certain genes, according to a preprint. medRxiv