Michael Ehlers
Neuroscience Chief Scientific Officer
Pfizer
From this contributor
A cautionary tale for autism drug development
Poorly designed animal drug studies for motor disorders have led to spurious conclusions for the clinical trials that follow. This may be even more true for autism research, says Michael Ehlers.
SHANK mutations converge at neuronal junctions in autism
SHANK3, one of the strongest candidate genes for autism, has the potential to be a molecular entry point into understanding the synaptic, developmental and circuit origins of the disorder.
SHANK mutations converge at neuronal junctions in autism
Drug zone
Rodent and stem cell models remain challenging for developing psychiatric drugs, says Michael Ehlers, chief scientific officer of neuroscience at Pfizer.
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Human-specific duplicates of SRGAP2 prolong cortical development by manipulating SYNGAP, an autism-linked protein that slows synaptic growth.
Protein tug-of-war controls pace of synaptic development, sets human brains apart
Human-specific duplicates of SRGAP2 prolong cortical development by manipulating SYNGAP, an autism-linked protein that slows synaptic growth.
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Nociceptors tamp down the production of reactive oxygen species in response to heat, chemical irritants or toxins.
Vicente Raja brings ecological psychology concepts to neuroscience
He suggests neuroscientists should pay more attention to the principles of Gibsonian ecological psychology, such as affordances, ecological information and resonance, to better explain perception and action.
Vicente Raja brings ecological psychology concepts to neuroscience
He suggests neuroscientists should pay more attention to the principles of Gibsonian ecological psychology, such as affordances, ecological information and resonance, to better explain perception and action.