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Liset de la Prida explains how neuron subtypes may control the activity of large neural populations, from manifolds to ripples

De la Prida’s work analyzing the varieties of sharp wave ripples in the hippocampus led to her discovery that specific types of neurons control the properties of neural manifolds.

By Paul Middlebrooks
22 April 2026 | 104 min watch

In this episode of “Bain Inspired,” Paul Middlebrooks talks with Liset de la Prida, director of the Centro de Neurociencias Cajal at the Instituto Cajal. Neural manifolds promise to explain how large populations of interacting neurons coordinate their activity to implement cognition, but most work in this area ignores the details of the neurons themselves. De la Prida has found that specific neuron types control the formation and function of manifolds, suggesting a way to bridge dynamic neural activity across scales—a key to unraveling the complexity of our brains. Read more from de la Prida: From genes to dynamics: Examining brain cell types in action may reveal the logic of brain function.

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