Depression

Illustration of a sparkly brain.

What, if anything, makes mood fundamentally different from memory?

To better understand mood disorders—and to develop more effective treatments—should we target the brain, the mind, the environment or all three?

By Nicole Rust
8 April 2024 | 8 min read
Image of a red rectangle against a gray background.
Ethics Microphone

FDA describes ‘objectionable conditions’ at New York State Psychiatric Institute

The facility’s institutional review board failed to report a 2021 incident and “serious and ongoing noncompliance” by a principal investigator, according to a letter released by the federal agency this week.

By Brendan Borrell
2 April 2024 | 6 min listen
Research image of microglia in rats.

Temperament is innate but hackable, animal studies suggest

Emotional reactivity and vulnerability to stress are largely inherited in rodents — but can be modified in early life by targeting inflammation-related cells or even just adjusting an animal’s environment.

By Holly Barker
23 January 2024 | 8 min read
Photograph of a doctor and nurse checking a patient’s temperature and taking notes.
Spectrum Microphone

Co-occurring conditions in autistic teens increase with age

The most prevalent conditions include obesity, neurological disorders, anxiety and attention-deficit/hyperactivity disorder.

By Calli McMurray
8 August 2023 | 1 min read
Ethics Microphone

Exclusive: Shake-up at top psychiatric institute following suicide in clinical trial

The New York State Psychiatric Institute in New York City is undergoing an audit and a change in leadership following a suicide that occurred during one of its clinical trials.

By Brendan Borrell
31 July 2023 | 5 min listen
Illustration of hybrid objects: part light bulb, part lab vial, some in blue and some in red to signify null and replicated results.

Prenatal exposures; Angelman trial suspension; autistic adult well-being

This month’s issue of the Null and Noteworthy newsletter breaks down some negative results involving prenatal exposures, an experimental treatment for Angelman syndrome, and the role that age at autism diagnosis plays in subsequent outcomes, and more.

By Emily Harris
17 July 2023 | 4 min read
Photograph of a white man in a green sweater sitting on a yellow sofa near a large window.
Retraction Microphone

Flawed protocol for levodopa clinical trial brings retractions

The retracted studies mar hope for the drug’s use in depression.

By Brendan Borrell
9 May 2023 | 4 min listen
Illustration of hybrid objects: part light bulb, part lab vial, some in blue and some in red to signify null and replicated results.

Null and Noteworthy: Reinforcing rigor; medication medley

This month’s newsletter highlights findings on the use of three medication types during pregnancy.

By Emily Harris
14 December 2022 | 4 min read
Illustration of hybrid objects: part light bulb, part lab vial, some in blue and some in red to signify null and replicated results.

Null and Noteworthy: COVID-19 conclusions; diagnosis duplication; oxytocin again

This month’s newsletter explores the pandemic’s effects on autism rates, trends in co-occurring mental health conditions, and the impact of intranasal oxytocin.

By Emily Harris
10 November 2022 | 5 min read
Conceptual illustration of two DNA helixes with several overlapping portions showing common and differing genes.
Spectrum Microphone

Genome scan spots common variant differences between autism and ADHD

Common variants in five regions of the genome may determine whether someone has one condition versus the other.

By Charles Q. Choi
12 October 2022 | 5 min read

Explore more from The Transmitter

Research image of neurons in the fly’s ventral nerve cord.

New connectomes fly beyond the brain

Researchers are mapping the neurons in Drosophila’s ventral nerve cord, where the central nervous system meets the rest of the body.

By Laura Dattaro
26 July 2024 | 7 min read
Illustration of researchers talking to laypeople amidst strands of DNA.

Building an autism research registry: Q&A with Tony Charman

A purpose-built database of participants who have shared genomic and behavioral data could give clinical trials a boost, Charman says.

By Cathleen O’Grady
25 July 2024 | 8 min read

Cerebellar circuit may convert expected pain relief into real thing

The newly identified circuit taps into the brain’s opioid system to provide a top-down form of pain relief.

By Angie Voyles Askham
24 July 2024 | 6 min read