The big picture

Recent articles

Researchers ask colleagues to weigh in on important topics in the field.

Illustration of pixelated AI models.

Models at the speed of thought: How AI coding is reshaping theoretical neuroscience

Agentic coding makes it possible to specify a neuroscience model in hours instead of months. Seven neuroscientists weigh in on what that tectonic change may bring to the field.

By Brian DePasquale
16 June 2026 | 17 min read
Illustration of a brain that is half organic texture and half geometric pattern.

Trading places: What happens when neuroscience turns into machine learning, and machine learning turns into neuroscience?

Neuroscience has become increasingly concerned with prediction, and machine learning with causal explanation, with each field adopting methods from the other. I asked eight experts to weigh in on what we stand to learn from this exchange.

By Samuel Gershman
23 March 2026 | 22 min read
Illustration of a series of shapes, with a few resembling human eyes.

The visual system’s lingering mystery: Connecting neural activity and perception

Figuring out how the brain uses information from visual neurons may require new tools. I asked 10 neuroscientists what experimental and conceptual methods they think we’re missing.

By Grace Lindsay
13 October 2025 | 24 min read
A drosophila connectome.

One year of FlyWire: How the resource is redefining Drosophila research

We asked nine neuroscientists how they are using FlyWire data in their labs, how the connectome has transformed the field and what new tools they would like to see in the future.

By Francisco J. Rivera Rosario
7 October 2025 | 17 min read
Illustration of a hand drawing lines between different points on the outline of a brain.

Beyond Newtonian causation in neuroscience: Embracing complex causality

The traditional mechanistic framework must give way to a richer understanding of how brains actually generate behavior over time.

By Luiz Pessoa
22 September 2025 | 20 min read
Hands arrange various shapes over a color background.

Emotion research has a communication conundrum

In 2025, the words we use to describe emotions matter, but their definitions are controversial. Here, I unpack the different positions in this space and the rationales behind them—and I invite 13 experts to chime in.

By Nicole Rust
5 September 2025 | 29 min read
Data streams into a transparent box.

Accepting “the bitter lesson” and embracing the brain’s complexity

To gain insight into complex neural data, we must move toward a data-driven regime, training large models on vast amounts of information. We asked nine experts on computational neuroscience and neural data analysis to weigh in.

By Eva Dyer, Blake Richards
26 March 2025 | 25 min read
Illustration of a funnel taking abstract shapes in at the top and spouting an organized flow of shapes out at the bottom.

To keep or not to keep: Neurophysiology’s data dilemma

An exponential growth in data size presents neuroscientists with a significant challenge: Should we be keeping all raw data or focusing on processed datasets? I asked experimentalists and theorists for their thoughts.

By Nima Dehghani
25 November 2024 | 24 min read
Illustration of an image of a landscape repeated over and over again, with some versions distorted and warped.

What makes memories last—dynamic ensembles or static synapses?

Teasing out how different subfields conceptualize central terms might help move this long-standing debate forward. I asked eight scientists to weigh in.

By Jason Shepherd
14 October 2024 | 30 min read
Collage of different images of brains and mechanical devices in the background with a suitcase in the foreground.

What are mechanisms? Unpacking the term is key to progress in neuroscience

Mechanism is a common and powerful concept, invoked in grant calls and publication guidelines. But scientists use it in different ways, making it difficult to clarify standards in the field. We asked nine scientists to weigh in.

By Dani S. Bassett, Lauren N. Ross
7 October 2024 | 27 min read

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Explore more from The Transmitter

Illustration of birdsong, bird brain, and DNA.

This paper changed my life: Embracing an early model for naturalistic neuroscience

A 1992 PNAS paper showed how birdsong upregulates the expression of an immediate early gene in bird forebrains. The work revealed to Ribeiro the importance of studying molecular responses in naturalistic contexts.

By Sidarta Ribeiro
14 July 2026 | 4 min read
Illustration of an open journal featuring lines of text and small illustrations of eyes and mouths.

Major ischemic events in autistic people, and more

Here is a roundup of autism-related news and research spotted around the web for the week of 13 July.

By Jill Adams
14 July 2026 | 1 min read
Illustration of lucid dreaming.

Watching the mind build a world: Lucid dreaming as a model for generative perception

Lucid dreaming offers a rare opportunity to observe and probe perception from within.

By Magdalena Paluchowska
13 July 2026 | 8 min read