Macrocephaly

Recent articles

Research image of two fluorescent-stained organoids.

CRISPR gives autism-linked genes a boost, rescues functioning

A modified form of the gene-editing tool increases the expression of CHD8 and SCN2A, showing potential for autism therapies.

By Giorgia Guglielmi
23 May 2024 | 5 min read
Research image of organoids in the forebrain.

Head size parts autism into two major subtypes

An imbalance in the number of excitatory neurons in early brain development may account for the difference.

By Charles Q. Choi
12 September 2023 | 4 min read
Composite research image of organoids at several stages of development.

Genetic background sways effects of autism-linked mutation

Experiments offer clues to why certain mutations are associated with autism in some people and not others.

By Charles Q. Choi
18 May 2023 | 4 min read
A white mouse, brown mouse and black mouse stand inside a wooden circle against a blue background.

CHD8 mutation in 33 mouse strains yields range of traits

The findings put genetic background forward to help explain autism’s heterogeneity.

By Peter Hess
3 February 2023 | 5 min read
Geometric black-and-white brain model over a grid.

Excess of ‘don’t eat me’ cell signals may drive brain enlargement in autism

The signal, called CD47, is disrupted in autistic people who have a larger-than-average head.

By Peter Hess
22 November 2022 | 4 min read
Three scans of zebrafish brains.

Zebrafish point to new gene involved in brain overgrowth, autism

The gene, YTHDF2, has not previously been linked to autism.

By Katharine Gammon
1 November 2022 | 2 min read
A woman in a lab coat types at a computer.

New diagnostic code for PTEN syndrome may spur research

The code may help scientists identify people with the autism-linked condition and recruit them into clinical trials.

By Nicholette Zeliadt
3 October 2022 | 4 min read

Different forms of autism have opposite problems with brain precursor cells

The cells’ altered proliferation rates hint at ways to diagnose and potentially treat autism earlier.

By Charles Q. Choi
10 June 2022 | 4 min read
Three views of zebrafish.

Novel gene linked to brain size in autistic people

The gene, YTHDF2, may be one of several that contribute to an autism subtype marked by an unusually big brain.

By Laura Dattaro
16 May 2022 | 2 min read
organoids in early stages of development.

Organoids show how mutations in top autism gene may lead to brain overgrowth in people

The loss of CHD8, a top autism gene, speeds up the production of certain neurons and leads to overgrowth in spheres of cultured brain cells.

By Peter Hess
19 April 2022 | 3 min read

Explore more from The Transmitter

Human X and Y chromosomes.

Extra Y chromosomes are linked to autism

Data from people with more or fewer than two sex chromosomes could help answer questions around genetic protection and vulnerability.

By Grace Huckins
5 December 2024 | 5 min read
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Grace Hwang and Joe Monaco discuss the future of NeuroAI

Hwang and Monaco organized a recent workshop to hear from leaders in the field about how best to integrate NeuroAI research into the BRAIN Initiative.

By Paul Middlebrooks
4 December 2024 | 97 min listen
Illustration of an open journal featuring lines of text and small illustrations of eyes and mouths.

Anti-seizure medications in pregnancy; TBR1 gene; microglia

Here is a roundup of autism-related news and research spotted around the web for the week of 2 December.

By Jill Adams
3 December 2024 | 1 min read