Theoretical neuroscience

Recent articles

Illustration of three steps to build an origami polyhedron.

Dimensionality—neuroscience’s red herring?

Placing too much emphasis on a specific interpretation of dimensionality, or treating it as an end-all quantification of some aspect of neural computation, may hinder progress in understanding the brain.

By Matthew Perich
7 September 2026 | 8 min read

How energy determines where proteins are produced in neurons

Tatjana Tchumatchenko explains how mathematical modeling elucidates whether ion-channel proteins are produced locally in the soma or in the dendrites.

By Gaute Einevoll
26 August 2026 | 104 min listen
Covers of The Transmitter's summer book picks.

Five new neuroscience books, and other notable titles from 2026

The Transmitter’s summer reading list includes an autopsy of the Human Brain Project, an overview of the neuroscience of motherhood and a memoir from a pioneer in Huntington’s disease research.

By Francisco J. Rivera Rosario
25 August 2026 | 7 min read

Reverse engineering neural circuits; success stories from computational neuroscience

Kevin Mitchell talks with Timothy Behrens about ring attractors, the role of innate structure, and an expanded view of cognitive maps.

By Kevin Mitchell
6 August 2026 | 4 min read
A brain shape outlined in cylindrical dials with multi colored wires stretched between them.

Transforming AI models into useful model organisms

These systems were not built to explain the brain. But treating them as model organisms that we can perturb and evolve will move us closer to that goal.

By Mariya Toneva
22 June 2026 | 6 min read
Illustration of pixelated AI models.

Models at the speed of thought: How AI coding is reshaping theoretical neuroscience

Agentic coding makes it possible to specify a neuroscience model in hours instead of months. Seven neuroscientists weigh in on what that tectonic change may bring to the field.

By Brian DePasquale
16 June 2026 | 17 min read

Romain Brette reveals fundamental flaws in commonly assumed neuroscience concepts

His new book, “The Brain, In Theory,” offers alternatives to many of the computer science frameworks currently driving theoretical neuroscience.

By Paul Middlebrooks
8 April 2026 | 131 min listen
Book cover of The Brain, In Theory by Romain Brette.

‘The Brain, In Theory,’ an excerpt

In his new book, Brette pushes back against theories that describe the brain as a “biological computer.” In this excerpt from Chapter 4, he challenges equating brain evolution with programming, and the universality of neural network models.

By Romain Brette
7 April 2026 | 5 min read

What a bird’s-eye view of half a million papers reveals about neuroscience

New research uses artificial-intellligence-driven bibliometrics to map the structural organization of neuroscience across 25 years. The field it reveals is at once thriving and theoretically adrift.

By Mac Shine
6 April 2026 | 3 min read

Explore more from The Transmitter

Mouse cortical organoid.

Hasty stem cells highlight potential limitation with cortical organoids

The models recapitulate many key developmental processes, but some radial glial cells in mouse organoids make neurons earlier than they should.

By Giorgia Guglielmi
22 September 2026 | 4 min read
Illustration of an open journal featuring lines of text and small illustrations of eyes and mouths.

Two populations of neurons, two effects on sociability; and more

Here is a roundup of autism-related news and research spotted around the web for the week of 21 September.

By Jill Adams
22 September 2026 | 2 min read

Finding the Rett syndrome gene and ways to fix it

Kevin Mitchell talks with Huda Zoghbi about her work identifying the MECP2 gene, its role in the brain and therapies to address its dysfunction.

By Kevin Mitchell
21 September 2026 | 4 min read