SHANK2

Recent articles

Mouse brain slices showing the effects of SHANK2 and SHANK3 deletions.

Double SHANK knockout highlights brain circuit’s social role

Mice missing the autism-linked SHANK2 and SHANK3 genes in their retrosplenial cortex have trouble distinguishing between novel and familiar mice.

By Angie Voyles Askham
19 October 2022 | 5 min read
A family of Macaques aat the Yerkes National Primate Research Center Field Station, Lawrenceville, Georgia.

Macaques’ social skills tied to variation in autism-linked genes

Genetics strongly influences some aspects of the monkey’s social behavior, including tendencies to solicit grooming and sit or play alone.

By Chloe Williams
7 March 2022 | 5 min read
Oil and water with colors behind: blue, green, yellow and red.

How microscopic ‘condensates’ in cells might contribute to autism

A controversial idea about how cells compartmentalize their contents into droplets — like beads of oil in water — could be key to understanding autism, says Julie Forman-Kay.

By Angie Voyles Askham
23 February 2021 | 7 min read

Mechanical tracker measures social activity of multiple mice for days

A new system enables researchers to automatically track the social behavior of up to four mice for days at a time.

By Sarah DeWeerdt
28 June 2019 | 2 min read
grid of lab grown neurons

New method creates uniform cultures of lab-grown neurons

A new technique leads to neuron cultures of consistent quality, enabling scientists to study how autism mutations alter neurons.

By Chloe Williams
16 May 2019 | 2 min read

Rats with mutant SHANK genes show autism-like behaviors

Researchers have engineered two new rats with mutations in a family of genes that function at neuronal junctions, they reported today at the 2014 International Meeting for Autism Research in Atlanta.

By Jessica Wright
16 February 2017 | 4 min read
Spectrum from The Transmitter.

Neighboring mutations in gene may spawn separate conditions

Two seemingly similar mutations in the SHANK3 gene have divergent effects on the brain and behavior.

By Jessica Wright
25 January 2016 | 4 min read
Spectrum from The Transmitter.

Small snippets of genes may have big effects in autism

Small pieces of DNA within genes, dubbed ‘microexons,’ are abnormally regulated in people with autism, suggests a study of postmortem brains.

By Kate Yandell
22 January 2015 | 5 min read
Spectrum from The Transmitter.

Family of autism-linked proteins helps neurons communicate

The SHANK family of proteins, some of which are strong autism candidates, work together to facilitate brain signaling, according to unpublished results presented yesterday at the 2014 Society for Neuroscience annual meeting in Washington, D.C.

By Jessica Wright
16 November 2014 | 3 min read
Spectrum from The Transmitter.

SHANK3 mutations turn up in high proportion of autism cases

About 2 percent of people who have both autism and intellectual disability carry harmful mutations in SHANK3, a protein that helps organize the connections between neurons, according to a study published 4 September in PLoS Genetics.

By Jessica Wright
18 September 2014 | 4 min read

Explore more from The Transmitter

INSAR takes ‘intentional break’ from annual summer webinar series

The International Society for Autism Research cited a need to “thoughtfully reimagine” its popular online program before resuming it in 2026.

By Lauren Schenkman
30 June 2025 | 4 min read
Research image showing that activity in single neurons spikes when a person encodes sequential items into working memory.

Null and Noteworthy: Neurons tracking sequences don’t fire in order

Instead, neurons encode the position of sequential items in working memory based on when they fire during ongoing brain wave oscillations—a finding that challenges a long-standing theory.

By Laura Dattaro
30 June 2025 | 4 min read
A hand points to a chalkboard with an astrocyte on it.

How to teach this paper: ‘Neurotoxic reactive astrocytes are induced by activated microglia,’ by Liddelow et al. (2017)

Shane Liddelow and his collaborators identified the factors that transform astrocytes from their helpful to harmful form. Their work is a great choice if you want to teach students about glial cell types, cell culture, gene expression or protein measurement.

By Ashley Juavinett
30 June 2025 | 10 min read