Alzheimer’s disease
Reviving ‘inside-out’ hypothesis of amyloid beta to explain Alzheimer’s mysteries
New research is resurfacing old ideas about where the protein forms the disease’s hallmark plaques.
![Image of amyloid beta plaques.](https://www.thetransmitter.org/wp-content/uploads/2024/05/1200-amyloid-beta-plaque-origins-neuroscience-transmitter-1024x683.webp)
Reviving ‘inside-out’ hypothesis of amyloid beta to explain Alzheimer’s mysteries
New research is resurfacing old ideas about where the protein forms the disease’s hallmark plaques.
How inbreeding almost tanked an up-and-coming model of Alzheimer’s disease
But new genetic analyses and behavioral assays have made the Chilean degu a viable model again, researchers say.
![Picture of two Degus in a cage.](https://www.thetransmitter.org/wp-content/uploads/2024/05/DeguLede-1200-1024x692.webp)
How inbreeding almost tanked an up-and-coming model of Alzheimer’s disease
But new genetic analyses and behavioral assays have made the Chilean degu a viable model again, researchers say.
Carol Jennings, whose family’s genetics informed amyloid cascade hypothesis, dies at 70
Her advocacy work aided the discovery of a rare inherited form of early-onset Alzheimer’s disease and helped connect affected people with researchers.
![Photograph of Carol Jennings.](https://www.thetransmitter.org/wp-content/uploads/2024/04/1200-carol-jenning-obituary-neuroscience-transmitter-1024x683.webp)
Carol Jennings, whose family’s genetics informed amyloid cascade hypothesis, dies at 70
Her advocacy work aided the discovery of a rare inherited form of early-onset Alzheimer’s disease and helped connect affected people with researchers.
Alzheimer’s scientist to correct two papers because of data inconsistencies
Anonymous commenters raised concerns about the statistical methods that Soyon Hong and her colleagues used in their work.
![Red pencil leans on a stack of white paper](https://www.thetransmitter.org/wp-content/uploads/2024/03/Edit-papers-1200-1024x692.webp)
Alzheimer’s scientist to correct two papers because of data inconsistencies
Anonymous commenters raised concerns about the statistical methods that Soyon Hong and her colleagues used in their work.
We found a major flaw in a scientific reagent used in thousands of neuroscience experiments — and we’re trying to fix it.
As part of that ambition, we launched a public-private partnership to systematically evaluate antibodies used to study neurological disease, and we plan to make all the data freely available.
![Abstract illustration of antibodies scattered against a peach-colored background.](https://www.thetransmitter.org/wp-content/uploads/2024/01/1200-edwards-open-neuroscience-transmitter-1024x683.webp)
We found a major flaw in a scientific reagent used in thousands of neuroscience experiments — and we’re trying to fix it.
As part of that ambition, we launched a public-private partnership to systematically evaluate antibodies used to study neurological disease, and we plan to make all the data freely available.
Seen and heard: The Transmitter’s top multimedia stories in 2023
Our audio, video and photo highlights from the past year help to transport readers into scientists’ lives and research, and the lives of their study participants.
![Composite of images of fruit flies taking flight.](https://www.thetransmitter.org/wp-content/uploads/2023/12/1200-best-of-2023-multimedia-lede-1024x683.webp)
Seen and heard: The Transmitter’s top multimedia stories in 2023
Our audio, video and photo highlights from the past year help to transport readers into scientists’ lives and research, and the lives of their study participants.
Unmasking Alzheimer’s disease
People with early-onset Alzheimer’s disease describe why they enrolled in clinical trials through the Dominantly Inherited Alzheimer Network (DIAN), in a new book of portrait photography.
![](https://www.thetransmitter.org/wp-content/uploads/2023/11/LEDE_20210414_CARRIE_BRYAN_0025-e1700168295482-1024x748.webp)
Unmasking Alzheimer’s disease
People with early-onset Alzheimer’s disease describe why they enrolled in clinical trials through the Dominantly Inherited Alzheimer Network (DIAN), in a new book of portrait photography.
Explore more from The Transmitter
New connectomes fly beyond the brain
Researchers are mapping the neurons in Drosophila’s ventral nerve cord, where the central nervous system meets the rest of the body.
![Research image of neurons in the fly’s ventral nerve cord.](https://www.thetransmitter.org/wp-content/uploads/2024/07/lede-motormodules-1200-1024x692.webp)
New connectomes fly beyond the brain
Researchers are mapping the neurons in Drosophila’s ventral nerve cord, where the central nervous system meets the rest of the body.
Building an autism research registry: Q&A with Tony Charman
A purpose-built database of participants who have shared genomic and behavioral data could give clinical trials a boost, Charman says.
![](https://www.thetransmitter.org/wp-content/uploads/2024/07/1200_Charman-1024x687.webp)
Building an autism research registry: Q&A with Tony Charman
A purpose-built database of participants who have shared genomic and behavioral data could give clinical trials a boost, Charman says.
Cerebellar circuit may convert expected pain relief into real thing
The newly identified circuit taps into the brain’s opioid system to provide a top-down form of pain relief.
![](https://www.thetransmitter.org/wp-content/uploads/2024/07/paincircuit-1200-1024x692.webp)
Cerebellar circuit may convert expected pain relief into real thing
The newly identified circuit taps into the brain’s opioid system to provide a top-down form of pain relief.