Inhibitory signaling
What goes up must come down: New marker flags decreased neural activity
Phosphorylation of the metabolic enzyme pyruvate dehydrogenase inversely correlates with neural activity, offering scientists a tool to study inhibition for the first time.
What goes up must come down: New marker flags decreased neural activity
New template streamlines sharing clinical trial results
This month’s Going on Trial newsletter explores a new tool for communicating with clinical trial participants and their families, among other drug development news.
New template streamlines sharing clinical trial results
Vast diversity of human brain cell types revealed in trove of new datasets
The collection offers a glimpse into differences in cell composition — across people and brain regions — that may shape neural function.
Vast diversity of human brain cell types revealed in trove of new datasets
Some social issues in DYRK1A model mice stem from faulty inhibitory circuits
Alterations in inhibitory circuits and difficulties in social recognition characterize mice missing one copy of DYRK1A, a gene linked to autism.
Some social issues in DYRK1A model mice stem from faulty inhibitory circuits
Uncertainty and excitement surround one company’s cell therapy for epilepsy
After 10 years of work, Neurona may have the data to quiet its skeptics. But its ongoing clinical trial will be the ultimate test.
Uncertainty and excitement surround one company’s cell therapy for epilepsy
Trials test utility of EEG biomarkers for autism-related conditions
This month’s Going on Trial newsletter dives into an electroencephalography biomarker that could track the efficacy of treatments for dup15q and Angelman syndromes, among other drug development news.
Trials test utility of EEG biomarkers for autism-related conditions
‘VIP’ interneurons may drive autism traits in Dravet syndrome
The inhibitory cells misfire and contribute to social difficulties in mice that model the syndrome.
‘VIP’ interneurons may drive autism traits in Dravet syndrome
Trials of arbaclofen for autism yield mixed results
Autistic children taking the drug showed improvements in some behaviors but not in their social skills.
Trials of arbaclofen for autism yield mixed results
Cannabis compound rebalances signaling to quell seizures in mice
Cannabidiol (CBD) blocks the action of a molecule that drives an overexcitability feedback loop in a rodent model of epilepsy.
Cannabis compound rebalances signaling to quell seizures in mice
Going on Trial: Orphan drugs; CBD; bumetanide
This month’s newsletter takes a close look at the orphan drug program in the United States, several cannabis-based therapies and a secondary analysis of bumetanide, among other new developments in autism-related drug trials.
Explore more from The Transmitter
Cocaine, morphine commandeer neurons normally activated by food, water in mice
Confirming a long-held hypothesis, repeated exposure to the drugs alters neurons in the nucleus accumbens, the brain’s reward center, and curbs an animal’s urge for sustenance.
Cocaine, morphine commandeer neurons normally activated by food, water in mice
Confirming a long-held hypothesis, repeated exposure to the drugs alters neurons in the nucleus accumbens, the brain’s reward center, and curbs an animal’s urge for sustenance.
X chromosome inactivation; motor difficulties in 16p11.2 duplication and deletion; oligodendroglia
Here is a roundup of autism-related news and research spotted around the web for the week of 6 May.
X chromosome inactivation; motor difficulties in 16p11.2 duplication and deletion; oligodendroglia
Here is a roundup of autism-related news and research spotted around the web for the week of 6 May.
Decoding flies’ motor control with acrobat-scientist Eugenia Chiappe
The tiny performers steal the show in Chiappe’s sensorimotor-integration lab in Lisbon, Portugal.
Decoding flies’ motor control with acrobat-scientist Eugenia Chiappe
The tiny performers steal the show in Chiappe’s sensorimotor-integration lab in Lisbon, Portugal.