Synapses
Recent articles
Diverse autism genes derail common developmental pathways
Multiple genetic mouse models initially show delayed cortical development, but the animals’ molecular trajectories diverge within weeks after birth, a new study finds.
Diverse autism genes derail common developmental pathways
Multiple genetic mouse models initially show delayed cortical development, but the animals’ molecular trajectories diverge within weeks after birth, a new study finds.
Recording warning: Common brain signal may be misunderstood
High gamma activity in electrophysiologic recordings reflects widespread neural activity, not merely local firing, as previously thought.
Recording warning: Common brain signal may be misunderstood
High gamma activity in electrophysiologic recordings reflects widespread neural activity, not merely local firing, as previously thought.
Designer synapses edit brain circuits in living animals
The approach could help elucidate relationships between circuit structure and function, as well as the role of natural electrical synapses.
Designer synapses edit brain circuits in living animals
The approach could help elucidate relationships between circuit structure and function, as well as the role of natural electrical synapses.
Noncoding RNA sways core autism traits in mice
Small deletions in an X-linked RNA alter social and repetitive behaviors in male mice without broadly affecting learning or memory.
Noncoding RNA sways core autism traits in mice
Small deletions in an X-linked RNA alter social and repetitive behaviors in male mice without broadly affecting learning or memory.
Four protein synthesis pioneers win Kavli Prize in Neuroscience
Their research revealed how neurons synthesize proteins in previously unrecognized places.
Four protein synthesis pioneers win Kavli Prize in Neuroscience
Their research revealed how neurons synthesize proteins in previously unrecognized places.
‘Push-pull’ recipe for neural wiring used in multiple brain regions
A versatile pair of proteins steers neurons toward their targets and helps establish the brain’s sensory maps, new studies suggest.
‘Push-pull’ recipe for neural wiring used in multiple brain regions
A versatile pair of proteins steers neurons toward their targets and helps establish the brain’s sensory maps, new studies suggest.
Neuroscience needs single-synapse studies
Studying individual synapses has the potential to help neuroscientists develop new theories, better understand brain disorders and reevaluate 70 years of work on synaptic transmission plasticity.
Neuroscience needs single-synapse studies
Studying individual synapses has the potential to help neuroscientists develop new theories, better understand brain disorders and reevaluate 70 years of work on synaptic transmission plasticity.
Aging neurons outsource garbage disposal, clog microglia
Degradation-resistant proteins pass from neurons to glial cells in a process that may spread protein clumps around the brain, according to a study in mice.
Aging neurons outsource garbage disposal, clog microglia
Degradation-resistant proteins pass from neurons to glial cells in a process that may spread protein clumps around the brain, according to a study in mice.
Protein tug-of-war controls pace of synaptic development, sets human brains apart
Human-specific duplicates of SRGAP2 prolong cortical development by manipulating SYNGAP, an autism-linked protein that slows synaptic growth.
Protein tug-of-war controls pace of synaptic development, sets human brains apart
Human-specific duplicates of SRGAP2 prolong cortical development by manipulating SYNGAP, an autism-linked protein that slows synaptic growth.
Boosting SCN2A expression reduces seizures in mice
A modified form of CRISPR amps up expression of the gene—a strategy that could apply to other gene variations linked to autism.
Boosting SCN2A expression reduces seizures in mice
A modified form of CRISPR amps up expression of the gene—a strategy that could apply to other gene variations linked to autism.
Explore more from The Transmitter
Study questions DSM-5’s combining of autism traits
Sensory traits and restricted and repetitive behaviors are best understood as distinct but related characteristics, the new work suggests.
Study questions DSM-5’s combining of autism traits
Sensory traits and restricted and repetitive behaviors are best understood as distinct but related characteristics, the new work suggests.
After the ‘Thank you’ slide: When lived trauma enters trauma neuroscience
Trauma researchers need professional norms that allow brief, humane acknowledgment when acute trauma directly affects a scientific community.
After the ‘Thank you’ slide: When lived trauma enters trauma neuroscience
Trauma researchers need professional norms that allow brief, humane acknowledgment when acute trauma directly affects a scientific community.
Redefining underrepresentation in global neuroscience
Shifting the focus of equity initiatives from identity categories to structural barriers can reveal overlooked challenges and increase support and participation worldwide.
Redefining underrepresentation in global neuroscience
Shifting the focus of equity initiatives from identity categories to structural barriers can reveal overlooked challenges and increase support and participation worldwide.