Brain Inspired

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This podcast, hosted by Paul Middlebrooks, features in-depth conversations with neuroscientists studying natural and artificial intelligence, philosophy, consciousness and other related areas.

Tom Griffiths describes how neural networks, logic and probability theory together explain cognition

In his new book, “The Laws of Thought,” Griffiths shows how these three pillars of study complement one another and together form a solid foundation to eventually explain all of our cognition, from brain to mind.

By Paul Middlebrooks
11 March 2026 | 100 min listen

Three ecological psychologists on the right and wrong ways to use the field’s principles in neuroscience

Matthieu de Wit, Luis H. Favela and Vicente Raja weigh in on the recent trend of neuroscientists importing concepts from ecological psychology, the study of how an organism’s interactions with its environment explain perception and action.

By Paul Middlebrooks
25 February 2026 | 1 min read

Modern AI is simply no match for the complexity likely required for harboring consciousness, says Jaan Aru

He argues that our brain’s computations are of a completely different nature than any artificial intelligence because they take place across many spatial and temporal scales and are inextricably entwined with biological materials.

By Paul Middlebrooks
11 February 2026 | 1 min read

Michael Shadlen explains how theory of mind ushers nonconscious thoughts into consciousness

All of our thoughts, mostly nonconscious, are interrogations of the world, Shadlen says. The opportunity to report our answers to ourselves or others brings a thought into conscious awareness.

By Paul Middlebrooks
28 January 2026 | 1 min read

Tomaso Poggio on his quest for theories to explain the fundamental learning abilities of brains and machines

Thus far, engineering has outpaced theory in the science of intelligence. But Poggio is hopeful that theories can catch up.

By Paul Middlebrooks
14 January 2026 | 1 min read

Alex Maier argues that a scientific explanation of consciousness requires grounding in formalized mathematics

When it comes to discovering laws of nature for consciousness similar to those in physics, Maier argues that integrated information theory is the only game in town.

By Paul Middlebrooks
7 January 2026 | 1 min read

Can neuroscientists decode memories solely from a map of synaptic connections?

Five experts discuss the progress, possibilities and hurdles of decoding a “nontrivial” memory from an organism just by analyzing its brain connectivity patterns.

By Paul Middlebrooks
17 December 2025 | 1 min read

Tatiana Engel explains how to connect high-dimensional neural circuitry with low-dimensional cognitive functions

Neuroscientists have long sought to understand the relationship between structure and function in the vast connectivity and activity patterns in the brain. Engel discusses her modeling approach to discovering the hidden patterns that connect the two.

By Paul Middlebrooks
3 December 2025 | 1 min read

Does AI understand what it produces? Henk de Regt explores how we might assess understanding in machines and humans

Building on his philosophy of how scientists understand what they work on, de Regt is extending his approach to test understanding in machines.

By Paul Middlebrooks
19 November 2025 | 1 min read

Daniel Nicholson discusses how Schrödinger’s book ‘What is Life?’ shaped years of biology, research

Combing through historical archives, Nicholson discovered what drove Erwin Schrödinger to pen “What Is Life,” his famous "little book": Schrödinger feared that new discoveries in quantum physics would influence how we think about free will.

By Paul Middlebrooks
5 November 2025 | 1 min read

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Explore more from The Transmitter

Annette Dolphin.

Remembering Annette Dolphin, who helped explain gabapentin’s effects

The "intuitive" neuropharmacologist pushed against the status quo.

By Michael Eisenstein
13 March 2026 | 7 min read
Data visualization from a genome-wide association study.

Revised statistical bar extracts less-common variants from autism genetics studies

Adjusting genetic analyses could help plug autism’s heritability gap, according to a new preprint.

By Holly Barker
12 March 2026 | 4 min read
Illustration of dopamine neurons.

This paper changed my life: Talia Lerner reflects on dopamine neuron diversity and the value of simple experiments

In a 2011 Neuron study, Stephan Lammel and his colleagues showed that dopamine neurons with different projections have different physiological properties. The work inspired Lerner to think about how to challenge widely held assumptions in the field.

By Talia Lerner
11 March 2026 | 6 min read