Clinical trials

Recent articles

Illustration of a brain surrounded by a stylized silhouette of a human head with psychedelic colors and textures.

Why we need basic science to better understand the neurobiology of psychedelics

Despite the many psychedelics clinical trials underway, there is still much we don’t know about how these drugs work. Preclinical studies represent our best viable avenue to answer these lingering questions.

By Devin Effinger, Melissa Herman
1 October 2025 | 7 min listen
Bag of umbilical cord blood.

Why hype for autism stem cell therapies continues despite dead ends

After numerous tests, there is still no evidence that these experimental treatments help, so now is not the time to expand access to them.

By Paul Knoepfler
22 August 2025 | 6 min read
A clinician holds a clipboard while someone else sits on a couch.

Expediting clinical trials for profound autism: Q&A with Matthew State

Aligning Research to Impact Autism, a new initiative funded by the Sergey Brin Family Foundation, wants to bring basic science discoveries to the clinic faster.

By Lauren Schenkman
24 April 2025 | 8 min read
Photograph of a syringe.

What’s next for brain-directed gene therapy after death in Neurogene trial

The incident highlights that viral vectors can trigger deadly immune responses even when delivered directly to the nervous system.

By Calli McMurray
26 November 2024 | 6 min read
Bret Rutherford.

Former Columbia University psychiatrist committed research misconduct, says federal watchdog

Bret Rutherford, whose research was halted following a suicide in a clinical trial, falsely reported participant eligibility, according to the U.S. Office of Research Integrity.

By Brendan Borrell, Ellie Kincaid
8 October 2024 | 3 min read
Illustration of researchers talking to laypeople amidst strands of DNA.

Building an autism research registry: Q&A with Tony Charman

A purpose-built database of participants who have shared genomic and behavioral data could give clinical trials a boost, Charman says.

By Cathleen O’Grady
25 July 2024 | 8 min read
A hand holds a stack of speech bubbles.

Leveraging the power of community to strengthen clinical trials for rare genetic syndromes

Families can become not only participants but champions of these research efforts.

By Shafali Spurling Jeste
11 July 2024 | 7 min read
Image of a red rectangle against a gray background.

FDA describes ‘objectionable conditions’ at New York State Psychiatric Institute

The facility’s institutional review board failed to report a 2021 incident and “serious and ongoing noncompliance” by a principal investigator, according to a letter released by the federal agency this week.

By Brendan Borrell
2 April 2024 | 6 min listen
Composite of images of fruit flies taking flight.

Seen and heard: The Transmitter’s top multimedia stories in 2023

Our audio, video and photo highlights from the past year help to transport readers into scientists’ lives and research, and the lives of their study participants.

By The Transmitter
29 December 2023 | 3 min read
Three groups of people meet and mix at a crossroads.

Year in Review: Spectrum’s best in 2023

Here are five must-reads from our coverage of autism research over the past 12 months.

28 December 2023 | 4 min read

Explore more from The Transmitter

Illustration of a neuron.

New questions around motor neurons and plasticity

A researcher’s theory hangs muscle degeneration on a broken neural circuit.

By David Adam
10 October 2025 | 11 min listen
Research image of SCN2A neurons.

Boosting SCN2A expression reduces seizures in mice

A modified form of CRISPR amps up expression of the gene—a strategy that could apply to other gene variations linked to autism.

By Charles Q. Choi
9 October 2025 | 5 min read

Nikolay Kukushkin discusses his book, ‘One Hand Clapping: Unraveling the Mystery of the Human Mind’

He explains how meaning arises in the interactions found throughout nature and evolution, from molecules to minds.

By Paul Middlebrooks
8 October 2025 | 1 min read

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