In this “Brain Inspired” episode, Paul Middlebrooks leads a panel discussion at a satellite event hosted by Aspirational Neuroscience at this year’s Society for Neuroscience conference. The goal of the discussion was to determine whether and how we can decode memories, behaviors or cognitive functions by analyzing a brain’s connectome—a static map of its synaptic connections. Discussants included Michał Januszewski of Google Research, Sven Dorkenwald of the Allen Institute, Helene Schmidt of the Ernst Strüngmann Institute, Andrew Payne of E11 Bio and Randal Koene of the Carboncopies Foundation.
Can neuroscientists decode memories solely from a map of synaptic connections?
Five experts discuss the progress, possibilities and hurdles of decoding a “nontrivial” memory from an organism just by analyzing its brain connectivity patterns.
By
Paul Middlebrooks
17 December 2025 | 1 min read
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