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Nicole Rust on her new book, ‘Elusive Cures’

Rust discusses how understanding the brain as a complex dynamical system will help us accelerate treatments for brain disorders.

By Paul Middlebrooks
18 June 2025 | 93 min watch

In this “Brain Inspired” episode, Paul Middlebrooks talks with Nicole Rust, professor of psychology at the University of Pennsylvania. Last week, Rust published a new book entitled “Elusive Cures: Why Neuroscience Hasn’t Solved Brain Disorders–and How We Can Change That” (Read an excerpt here). Rust explains how her shift in thinking of the brain as being governed by domino-like cause and effect to thinking of it as an adaptive complex system has given her new hope that neuroscience can begin to effectively treat brain and mental disorders.

Read the transcript.

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