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Romain Brette reveals fundamental flaws in commonly assumed neuroscience concepts

His new book, “The Brain, In Theory,” offers alternatives to many of the computer science frameworks currently driving theoretical neuroscience.

By Paul Middlebrooks
8 April 2026 | 1 min read

In this episode of “Bain Inspired,” Paul Middlebrooks talks with Romain Brette, research director in computational and theoretical neuroscience at the Institute of Intelligent Systems and Robotics. Brette breaks down why the notions of coding, information, representations, computation and prediction are insufficient to explain cognition in the brain. Instead, he says, we need to embrace the processes and behaviors essential to living organisms. 

Read an excerpt from Brette’s new book, “The Brain, In Theory.”

Read the transcript.

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