Connectivity
Drafting a ‘dysfunctome’: Faulty connections to subthalamic nucleus characterize disparate brain disorders
Different circuits between the millimeters-wide structure and the cortex go awry in Tourette syndrome, obsessive-compulsive disorder, dystonia and Parkinson’s disease, a new study of human brain scans suggests.
Microglial overreaction to atypical neurons may drive autism
In mice and organoids lacking a neuronal protein, microglia prune synapses to excess.
Microglial overreaction to atypical neurons may drive autism
Noisy brain may underlie some of autism’s sensory features
Random fluctuations in neuronal activity are more variable in a fragile X mouse model than in wildtype mice.
Noisy brain may underlie some of autism’s sensory features
Standout neuroscience news in 2023
Did you miss any of our favorite stories from the past year? Revisit them here.
What happens when a histopathologist teams up with computational modelers?
Answers emerge in my chat with Nicola Palomero-Gallagher, a rare example of someone who connects the brain’s microscopic constituents and macroscopic features.
What happens when a histopathologist teams up with computational modelers?
Plugging invisible gaps in the synaptic connectome
Two new maps of the roundworm nervous system detail how neurons communicate with short proteins called neuropeptides outside synapses.
Plugging invisible gaps in the synaptic connectome
Full connectome of adult fruit fly completed, with help from citizen scientists
The map, by far the largest one of an entire brain to date, contains 130,000 neurons and 53 million synapses.
Full connectome of adult fruit fly completed, with help from citizen scientists
Robotic headgear records brain activity in moving mice
The tool could help researchers study the neurobiology of natural behaviors, scientists say.
Robotic headgear records brain activity in moving mice
Repurposed electronics lens spies neurons across entire mouse brain
When combined with tissue-inflation methods, the microscope can image axons without the need for tissue slicing, the researchers say.
Repurposed electronics lens spies neurons across entire mouse brain
Statistical method improves behavioral predictions from fMRI
The framework, inspired by the polygenic risk score, considers the cumulative effect of neuronal connections.
Statistical method improves behavioral predictions from fMRI
Explore more from The Transmitter
The question of regeneration—an excerpt from ‘Periphery: How Your Nervous System Predicts and Protects Against Disease’
In his recent book, Moses Chao makes the case that the peripheral nervous system can warn of future illnesses.
The question of regeneration—an excerpt from ‘Periphery: How Your Nervous System Predicts and Protects Against Disease’
In his recent book, Moses Chao makes the case that the peripheral nervous system can warn of future illnesses.
RNA drug corrects calcium signaling in chimeric model of Timothy syndrome
The drug, tested in rats that have human neurons, could enter clinical testing as early as next year, researchers say.
RNA drug corrects calcium signaling in chimeric model of Timothy syndrome
The drug, tested in rats that have human neurons, could enter clinical testing as early as next year, researchers say.
How to use race and ethnicity data responsibly in neuroscience research
Follow these four tips to avoid using the information in problematic ways, including as a proxy for environmental variables.
How to use race and ethnicity data responsibly in neuroscience research
Follow these four tips to avoid using the information in problematic ways, including as a proxy for environmental variables.