IQ

Brain organoid size matches intensity of social problems in autistic people

Overgrown organoids could point to mechanisms underlying profound autism.

By Holly Barker
18 July 2024 | 5 min read
Illustration of DNA methylation.
Spectrum Microphone

‘Polygenic risk scores’ for autism, explained

These scores — composite measures of a person’s autism-linked common genetic variants — cannot predict an autism diagnosis but could help researchers better understand the condition’s underlying biology.

By Giorgia Guglielmi
23 May 2023 | 4 min read
Conceptual illustration of a door leading from one area of the brain to another area of the brain.
Spectrum Microphone

Autism’s genetic heterogeneity evident in brain connectivity patterns

The results highlight the importance of subgrouping study participants based on their underlying genetics, the researchers say.

By Angie Voyles Askham
27 September 2022 | 5 min read
An abstract "funding mechanism" featuring dollar bills alongside tubes, beakers and wires
Spectrum Microphone

New program offers $35K grants to study ‘profound autism’

People who have ‘profound autism’ — those with severe intellectual disability, limited communication abilities or both — tend to be excluded from research. The Autism Science Foundation seeks to change that.

By Peter Hess
18 July 2022 | 5 min read
Child with colorful tactile puzzle and clinician or therapist.
Spectrum Microphone

Autism without intellectual impairments more common than previously reported

Almost 60 percent of autistic people may have an average or above-average intelligence quotient, according to a new longitudinal study.

By Jonathan Moens
1 December 2021 | 2 min read
Child makes a row of flowers on the ground.
Spectrum Microphone

Repetitive behaviors wax and wane among autistic youth

Some types of restricted and repetitive behaviors become more prevalent among autistic children and teenagers over time, depending on their age and intellectual ability, whereas others decrease.

By Peter Hess
20 September 2021 | 2 min read
Illustration shows yellow landscape with blue sections and a lot of trains on paths with kids on the trains, going different directions.
Spectrum Microphone

Mapping the futures of autistic children

Researchers can roughly project what autistic children's lives will look like years down the road. But how good is their crystal ball — and what are its benefits?

By Elizabeth Svoboda
14 July 2021 | 22 min listen
researchers analyzing a big change in a DNA helix

Evolutionary approach reveals impact of missense variants in autism

Cross-species comparisons can help make sense of subtle genetic variants in people with autism and identify hundreds of new genes that may contribute to the condition.

By Chloe Williams
7 July 2021 | 5 min read
Child in an MEG machine
Spectrum Microphone

Making neuroimaging accessible for more autistic children

A new protocol aims to help researchers include more autistic people — especially those who are minimally verbal or have intellectual disability — in imaging studies.

By Laura Dattaro
6 April 2021 | 8 min read
Brain made of DNA strands on a background of molecule shapes
Spectrum Microphone

There are no autism-specific genes, just brain genes

There is not yet a single example of a gene that, when mutated, increases the likelihood of autism but not of other neurodevelopmental conditions, including intellectual disability.

By David Ledbetter, Scott Myers
23 March 2021 | 5 min read

Explore more from The Transmitter

Research image of neurons in the fly’s ventral nerve cord.

New connectomes fly beyond the brain

Researchers are mapping the neurons in Drosophila’s ventral nerve cord, where the central nervous system meets the rest of the body.

By Laura Dattaro
26 July 2024 | 7 min read
Illustration of researchers talking to laypeople amidst strands of DNA.

Building an autism research registry: Q&A with Tony Charman

A purpose-built database of participants who have shared genomic and behavioral data could give clinical trials a boost, Charman says.

By Cathleen O’Grady
25 July 2024 | 8 min read

Cerebellar circuit may convert expected pain relief into real thing

The newly identified circuit taps into the brain’s opioid system to provide a top-down form of pain relief.

By Angie Voyles Askham
24 July 2024 | 6 min read