Locus coeruleus

Recent articles

The brain’s quiet conductor: How hidden cells fine-tune arousal

New research published today suggests that the pericoeruleus acts as a kind of micromanager of arousal, selectively inhibiting different subgroups of locus coeruleus neurons depending on the behavioral context.

By Mac Shine
7 May 2025 | 59 min watch
Three sleeping mice.

Fleeting sleep interruptions may help brain reset

Brief, seconds-long microarousals during deep sleep “ride on the wave” of locus coeruleus activity in mice and correlate with periods of waste clearing and memory consolidation, new research suggests.

By Shaena Montanari
13 January 2025 | 5 min read
Micrograph comparing locus coeruleus of 16p11.2 mutant mice and control mice show less active noradrenergic neurons in mutant mice.

Circuit flaw underlies motor learning issues in autism mouse model

Mice missing a copy of chromosomal region 16p11.2 are slow to learn motor tasks and have dysfunction in a brain circuit associated with stress and movement, according to a new study. Normalizing this circuit's activity corrects the learning deficit.

By Peter Hess
12 April 2021 | 4 min read

Explore more from The Transmitter

Bag of umbilical cord blood.

Why hype for autism stem cell therapies continues despite dead ends

After numerous tests, there is still no evidence that these experimental treatments help, so now is not the time to expand access to them.

By Paul Knoepfler
22 August 2025 | 6 min read
Research image of cortical maps of somatosensation.

Adult human cortex does not reorganize after amputation

The results from a new longitudinal study contradict classic findings in monkeys but may not warrant a rewriting of the textbooks just yet.

By Angie Voyles Askham
21 August 2025 | 8 min listen
A James Hudspeth.

Remembering A. James Hudspeth, hair cell explorer

Hudspeth, who died 16 August at age 79, devoted his 50-year career to untangling how the ear converts sound into electrical signals.

By Calli McMurray
21 August 2025 | 7 min read

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