Maternal infection
Microglial overreaction to atypical neurons may drive autism
In mice and organoids lacking a neuronal protein, microglia prune synapses to excess.
![Research image of microglia in mice.](https://www.thetransmitter.org/wp-content/uploads/2023/12/1200-microglia-pruning-transmitter-neuroscience-1024x683.webp)
Microglial overreaction to atypical neurons may drive autism
In mice and organoids lacking a neuronal protein, microglia prune synapses to excess.
Immune-activation model mice escape infantile amnesia, retain early memories
Male pups born to mothers treated with immune-stimulating molecules show autism-like behaviors and, unlike wildtype animals, do not lose memories formed during early life.
![A research image of a mouse brain](https://www.thetransmitter.org/wp-content/uploads/2024/01/1200-spectrum-neuroscience-autism-transmitter-infantile-amnesia-copy-1024x683.webp)
Immune-activation model mice escape infantile amnesia, retain early memories
Male pups born to mothers treated with immune-stimulating molecules show autism-like behaviors and, unlike wildtype animals, do not lose memories formed during early life.
Atlas charts cells of human placenta, uterus across early pregnancy
A new resource gives an unparalleled look at how fetal placental cells attach to the uterine wall and remodel maternal blood vessels to access nutrients.
![A multiplexed image of human decidua.](https://www.thetransmitter.org/wp-content/uploads/2023/07/1200-placenta-map-final-autism.png)
Atlas charts cells of human placenta, uterus across early pregnancy
A new resource gives an unparalleled look at how fetal placental cells attach to the uterine wall and remodel maternal blood vessels to access nutrients.
Immune molecule alters cellular makeup of human brain organoids
The changes may help explain the link between maternal infection and autism, though more research is needed.
![Research image of radial glial cells in a human brain organoid.](https://www.thetransmitter.org/wp-content/uploads/2023/04/844-lede-final.png)
Immune molecule alters cellular makeup of human brain organoids
The changes may help explain the link between maternal infection and autism, though more research is needed.
Maternal immune response dulls male rats’ social radar
Male rats prenatally exposed to a maternal immune response have atypical responses to other rats in distress, according to a new study.
![Research image of the posterior insular cortex.](https://www.thetransmitter.org/wp-content/uploads/1970/01/844-maternal-immune-activation-final.png)
Maternal immune response dulls male rats’ social radar
Male rats prenatally exposed to a maternal immune response have atypical responses to other rats in distress, according to a new study.
The link between maternal infection and autism, explained
Having an infection during pregnancy is tied to a small increase in the chances of having an autistic child, but the connection may not be causal.
![Illustration of a pregnant woman seated next to a large diagram of the brain featuring chromosomes, bacteria and other microbes.](https://www.thetransmitter.org/wp-content/uploads/2022/12/1200-maternal-inflamation-1024x683.webp)
The link between maternal infection and autism, explained
Having an infection during pregnancy is tied to a small increase in the chances of having an autistic child, but the connection may not be causal.
Autism’s sex bias tied to glial, immune cell gene expression
The function of microglia and astrocytes in the brain may mediate the intersection of sex-differential biology and autism biology.
![Light micrograph of microglia cells stained with Rio Hortega’s silver carbonate method.](https://www.thetransmitter.org/wp-content/uploads/2022/11/Prenatal-brain-microglia-autism-844.jpg)
Autism’s sex bias tied to glial, immune cell gene expression
The function of microglia and astrocytes in the brain may mediate the intersection of sex-differential biology and autism biology.
Null and Noteworthy: COVID-19 conclusions; diagnosis duplication; oxytocin again
This month’s newsletter explores the pandemic’s effects on autism rates, trends in co-occurring mental health conditions, and the impact of intranasal oxytocin.
![Illustration of hybrid objects: part light bulb, part lab vial, some in blue and some in red to signify null and replicated results.](https://www.thetransmitter.org/wp-content/uploads/2022/05/lights_03-scaled.jpg)
Null and Noteworthy: COVID-19 conclusions; diagnosis duplication; oxytocin again
This month’s newsletter explores the pandemic’s effects on autism rates, trends in co-occurring mental health conditions, and the impact of intranasal oxytocin.
Null and Noteworthy: Medication timing; oxytocin amounts; sensory sameness
Parents’ health, treatment dosages and sensory perception feature in this month’s crop of null and replicated results.
![Illustration of hybrid objects: part light bulb, part lab vial, some in blue and some in red to signify null and replicated results.](https://www.thetransmitter.org/wp-content/uploads/2022/04/844_Null2_01.jpg)
Null and Noteworthy: Medication timing; oxytocin amounts; sensory sameness
Parents’ health, treatment dosages and sensory perception feature in this month’s crop of null and replicated results.
Registry review casts doubt on causal link between maternal infection and autism
The long-standing link between maternal infection during pregnancy and having a child with autism may reflect common genetic or environmental factors instead.
![A pregnant woman lies in a hospital bed.](https://www.thetransmitter.org/wp-content/uploads/2022/09/maternal-infection-pregnancy-autism-844.jpg)
Registry review casts doubt on causal link between maternal infection and autism
The long-standing link between maternal infection during pregnancy and having a child with autism may reflect common genetic or environmental factors instead.
Explore more from The Transmitter
New connectomes fly beyond the brain
Researchers are mapping the neurons in Drosophila’s ventral nerve cord, where the central nervous system meets the rest of the body.
![Research image of neurons in the fly’s ventral nerve cord.](https://www.thetransmitter.org/wp-content/uploads/2024/07/lede-motormodules-1200-1024x692.webp)
New connectomes fly beyond the brain
Researchers are mapping the neurons in Drosophila’s ventral nerve cord, where the central nervous system meets the rest of the body.
Building an autism research registry: Q&A with Tony Charman
A purpose-built database of participants who have shared genomic and behavioral data could give clinical trials a boost, Charman says.
![Illustration of researchers talking to laypeople amidst strands of DNA.](https://www.thetransmitter.org/wp-content/uploads/2024/07/1200_Charman-1024x687.webp)
Building an autism research registry: Q&A with Tony Charman
A purpose-built database of participants who have shared genomic and behavioral data could give clinical trials a boost, Charman says.
Cerebellar circuit may convert expected pain relief into real thing
The newly identified circuit taps into the brain’s opioid system to provide a top-down form of pain relief.
![](https://www.thetransmitter.org/wp-content/uploads/2024/07/paincircuit-1200-1024x692.webp)
Cerebellar circuit may convert expected pain relief into real thing
The newly identified circuit taps into the brain’s opioid system to provide a top-down form of pain relief.