Organoids
RNA drug corrects calcium signaling in chimeric model of Timothy syndrome
The drug, tested in rats that have human neurons, could enter clinical testing as early as next year, researchers say.
RNA drug corrects calcium signaling in chimeric model of Timothy syndrome
Microglial overreaction to atypical neurons may drive autism
In mice and organoids lacking a neuronal protein, microglia prune synapses to excess.
Microglial overreaction to atypical neurons may drive autism
On a bold mission to re-engineer brain parts
A European consortium is on a quest to restore typical brain activity in people with epilepsy, using a mash-up of custom organoids, microelectronics and artificial intelligence.
On a bold mission to re-engineer brain parts
Raising the bar for stem cell research: Q&A with Jack Mosher
New quality benchmarks for basic research involving stem cells promise to improve rigor and reproducibility, says Mosher, who helped develop the standards.
Raising the bar for stem cell research: Q&A with Jack Mosher
Method pinpoints cell-specific effects of autism-linked mutations
The approach, which combines CRISPR with single-cell analyses of organoids, suggests that intermediate progenitor cells are especially vulnerable to mutations associated with autism.
Method pinpoints cell-specific effects of autism-linked mutations
Genetic background sways effects of autism-linked mutation
Experiments offer clues to why certain mutations are associated with autism in some people and not others.
Genetic background sways effects of autism-linked mutation
Grafted organoids reveal how microglia adapt to shifting brain environments
The chimeric mouse model could provide a more realistic way to study microglia’s roles in brain conditions such as autism.
Grafted organoids reveal how microglia adapt to shifting brain environments
Immune molecule alters cellular makeup of human brain organoids
The changes may help explain the link between maternal infection and autism, though more research is needed.
Immune molecule alters cellular makeup of human brain organoids
‘Splice-switching’ strategy boosts SYNGAP1 expression
The approach improves the function of SYNGAP1-deficient neurons in vitro, but whether it will work in people remains unclear.
‘Splice-switching’ strategy boosts SYNGAP1 expression
Calming neurons to quell seizures: Q&A with Gabriele Lignani and Dimitri Kullmann
A new gene therapy approach for epilepsy tamps down neural activity on demand.
Calming neurons to quell seizures: Q&A with Gabriele Lignani and Dimitri Kullmann
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Inclusivity committee disbands in protest at Canadian neuroscience institute
The majority of an 11-person committee resigned from the group this week following news that a staff position overseeing equity, diversity and inclusion would not be renewed.
Inclusivity committee disbands in protest at Canadian neuroscience institute
The majority of an 11-person committee resigned from the group this week following news that a staff position overseeing equity, diversity and inclusion would not be renewed.
How to explore your scientific values and develop a vision for your field
As a new professor, I was caught off guard by one part of the job: my role as an evaluator.
How to explore your scientific values and develop a vision for your field
As a new professor, I was caught off guard by one part of the job: my role as an evaluator.
What neuroscientists should know—and what they can do—about changes to BRAIN initiative funding
Many grant proposals submitted to the program in the past year are unlikely to be funded, according to people within the National Institutes of Health. But scientist advocates are reaching out to congressional representatives to try to make changes for 2025.
What neuroscientists should know—and what they can do—about changes to BRAIN initiative funding
Many grant proposals submitted to the program in the past year are unlikely to be funded, according to people within the National Institutes of Health. But scientist advocates are reaching out to congressional representatives to try to make changes for 2025.