Mitochondria

Recent articles

Illustration of mitochondria as a kind of Stonehenge, with the shapes standing upright, casting shadows, against a blue sky.
Spectrum Microphone

Mitochondria mediate effects of PTEN mutations

Whole-genome sequencing data — which include information about mitochondrial DNA — offer clues to why mutations in the same gene can lead to autism or cancer.

By Katie Moisse
26 June 2023 | 4 min read
lllustration of the junction between two nerve cells.
Spectrum Microphone

Multi-omics study captures CNTNAP2’s far-ranging effects

The in-depth approach shows mutations in the autism-linked gene disrupt neuronal growth and communication, as well as mitochondrial gene expression.

By Charles Q. Choi
8 December 2022 | 4 min read

Unlocking the mitochondrial genome for autism research

The DNA specific to mitochondria is difficult to access, but new methods place its secrets within reach.

By Laura Dattaro
1 June 2022 | 5 min read
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Mitochondria: An energy explanation for autism

People with autism have more mutations than others do in both mitochondrial DNA and nuclear DNA that affects mitochondrial function.

By Laura Dattaro
22 November 2021 | 3 min watch
Stylized illustration combines flat color and 3D forms make up a mitochondria with human heads inside it.

Meet the ‘mitomaniacs’ who say mitochondria matter in autism

Clues that problems with mitochondria contribute to autism have been accumulating for decades. In the past five years, a mutant mouse and a flurry of findings have energized the field.

By Laura Dattaro
22 November 2021 | 18 min read

Dispatches from SfN 2021: Mitochondria, Rett therapy and oxytocin

These short reports from Spectrum journalists highlight some of the autism-related findings that caught our attention at the meeting this past week.

By Angie Voyles Askham, Laura Dattaro, Anna Goshua, Peter Hess
11 November 2021 | 9 min read
Transmission Electron micrograph shows mitochondria colored an aqua blue.
Spectrum Microphone

Changes to mitochondrial DNA spur autism-like traits in mice

Mice with a mutation in their mitochondrial DNA show altered brain activity, repetitive behaviors and reduced sociability, according to a new study.

By Laura Dattaro
17 February 2021 | 4 min read
White lab mouse sitting in a gloved hand.

Notable papers in autism research, 2020

Gene therapies and the factors influencing autism traits top Spectrum’s list of the 10 most notable research findings we covered in 2020.

By Spectrum
23 December 2020 | 4 min read
Micrograph of a mitochondria.

Fragile X syndrome traits may stem from leaky mitochondria

Plugging a leaky mitochondrial membrane may help fragile X neurons to mature and function more efficiently.

By Angie Voyles Askham
11 September 2020 | 6 min read
Magnified view of mitochondria in mice

Immune cells may underlie anxiety in autistic people

Some cases of anxiety, which often accompanies autism, may stem from a faulty immune system, a new study suggests — but some experts are skeptical.

By Nicholette Zeliadt
16 December 2019 | 5 min read

Explore more from The Transmitter

Parasite-based tool delivers MECP2 and other proteins to neurons

A method that uses a common brain parasite could help replenish the proteins deficient in Rett syndrome and other conditions.

By Giorgia Guglielmi
12 September 2024 | 4 min read
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Kim Stachenfeld on the dance between neuroscience and artificial intelligence

As a researcher at both Google DeepMind and Columbia University, Stachenfeld offers cross-disciplinary insight into how to understand the brain.

By Paul Middlebrooks
11 September 2024 | 92 min listen
World map displaying an analysis of years of life lost to suicide among autistic people in 2021.

PPP2R5D gene; social-communication intervention in infants; autism and suicide

Here is a roundup of autism-related news and research spotted around the web for the week of 9 September.

By Jill Adams
10 September 2024 | 2 min read