Mouse models

Recent articles

Two mice fighting.

Synaptic changes shape winning mice into bullies

When a mouse repeatedly defeats its opponents, brain circuits that underlie aggressive behaviors develop more stable connections, helping to ensure continual triumph, a new study shows.

By Claudia López Lloreda
14 October 2024 | 6 min read
Research image of neurons in the nucleus of the mouse solitary tract.

Cell population in brainstem coordinates cough, new study shows

The work also adds to a growing body of evidence showing that mice, and their genetic toolbox, can be used to study cough.

By Calli McMurray
6 September 2024 | 5 min read
Illustration of ketamine blocking open ion channels in active NMDA receptors, quieting the cells and disrupting downstream signaling involved in depression.

Ketamine targets lateral habenula, setting off cascade of antidepressant effects

The drug’s affinity for overactive cells in the “anti-reward” region may help explain its rapid and long-lasting results.

By Olivia Gieger
4 September 2024 | 6 min read
Illustrated portrait of Lin Tian.

Biosensors and being fearless with Lin Tian

Tian discusses protein function and structure, and the historic city in China where she was born.

By Brady Huggett
1 September 2024 | 62 min listen
Research image of fetal macaque brains.

Brain patterning in utero may be implicated in autism, other conditions

Genes tied to several conditions are expressed in regions that control neural stem cell fate within the first few months post-conception.

By Chloe Williams
1 August 2024 | 6 min read
Research image of neurons in the rostral anterior cingulate cortex (right, in green) sending signals to cells in the pontine nucleus (left, in yellow) to quell pain.

Cerebellar circuit may convert expected pain relief into real thing

The newly identified circuit taps into the brain’s opioid system to provide a top-down form of pain relief.

By Angie Voyles Askham
24 July 2024 | 6 min read

Widely used calcium imaging protocol can lead to spurious results, new paper cautions

The technique, which measures calcium currents as a proxy for neuronal firing, sometimes reports unusual and potentially misleading waves of activity in the hippocampus.

By Angie Voyles Askham
19 June 2024 | 0 min watch
Research image of brain activity

Connectivity takes U-turn in people with rare autism-linked mutations

Patterns of brain connectivity shift during puberty in people with deletion of the 22q11.2 chromosomal region.

By Holly Barker
30 May 2024 | 4 min read
A diagram of green neurnons

Cocaine, morphine commandeer neurons normally activated by food, water in mice

Confirming a long-held hypothesis, repeated exposure to the drugs alters neurons in the nucleus accumbens, the brain’s reward center, and curbs an animal’s urge for sustenance.

By Lauren Schenkman
8 May 2024 | 5 min read
Computer-generated illustration of disgusting green food.

‘It must be something I ate’ is hard-wired into the brain

Feeling sick reactivates “novel flavor” neurons, according to a new study in mice, and points to a dedicated circuit for learning to avoid unsafe food.

By Angie Voyles Askham
29 March 2024 | 6 min read

Explore more from The Transmitter

Research image of four brain scans with green areas indicating Parasagittal dura volume.

Okur-Chung neurodevelopmental syndrome; excess CSF; autistic girls

Here is a roundup of autism-related news and research spotted around the web for the week of 21 October.

By Jill Adams
22 October 2024 | 2 min read
A collage illustration of a woman’s face fragmented by a mosaic of X chromosomes, lines and shapes.

Brains, biases and amyloid beta: Why the female brain deserves a closer look in Alzheimer’s research

New results suggest the disease progresses differently in women, but we need more basic science to unpack the mechanisms involved.

By Rachel Buckley
22 October 2024 | 7 min read
Illustration of two neon-toned sets of concentric circles overlapping, with bright spots where they intersect.

Are brains and AI converging?—an excerpt from ‘ChatGPT and the Future of AI: The Deep Language Revolution’

In his new book, to be published next week, computational neuroscience pioneer Terrence Sejnowski tackles debates about AI’s capacity to mirror cognitive processes.

By Terrence Sejnowski
21 October 2024 | 12 min read