Null and Noteworthy

Recent articles

A monthly newsletter about neuroscience research that fails to support a hypothesis or replicates a previously proposed one.

Memory astrocytes.

Null and Noteworthy: Reanalysis contradicts report of immune memory in astrocytes

The analysis, which has not yet been peer reviewed, attributes the finding to misidentified immune cells instead.

By Laura Dattaro
30 April 2025 | 5 min read
Illustration of a line graph emanating from a beaker.

Null and Noteworthy: Reexamining registered reports

Out of 92 preregistered studies that resulted in published papers, only 15 had fully adhered to their preregistration details, according to a new analysis.

By Laura Dattaro
28 March 2025 | 5 min read
Illustration of a line graph emanating from a beaker.

Null and Noteworthy, relaunched: Probing a schizophrenia biomarker

This edition of Null and Noteworthy—the first for The Transmitter—highlights new findings about the auditory steady-state response in people with schizophrenia that, all within one study, somehow packed in a null result and a failed replication.

By Laura Dattaro
28 February 2025 | 5 min read
Illustration of hybrid objects: part light bulb, part lab vial, some in blue and some in red to signify null and replicated results.

The true meaning of a null result

This edition of Null and Noteworthy highlights results that reveal the difficulty in drawing definitive conclusions from data, including new findings about epidurals that contradict several others and an apparent null result on sex differences that may derive from “circular logic.”

By Laura Dattaro
14 August 2023 | 4 min read
Illustration of hybrid objects: part light bulb, part lab vial, some in blue and some in red to signify null and replicated results.

Prenatal exposures; Angelman trial suspension; autistic adult well-being

This month’s issue of the Null and Noteworthy newsletter breaks down some negative results involving prenatal exposures, an experimental treatment for Angelman syndrome, and the role that age at autism diagnosis plays in subsequent outcomes, and more.

By Emily Harris
17 July 2023 | 4 min read
Illustration of hybrid objects: part light bulb, part lab vial, some in blue and some in red to signify null and replicated results.

Null and Noteworthy: Modified MRI; father findings

This month’s newsletter tackles null findings from an attempted replication of a “revolutionary” MRI approach and an analysis of family genetics.

By Emily Harris
22 June 2023 | 4 min read
Illustration of hybrid objects: part light bulb, part lab vial, some in blue and some in red to signify null and replicated results.

Null and Noteworthy: Arbaclofen results; another oxytocin edition

New data from clinical trials of arbaclofen and oxytocin underscore the murkiness of null results. Plus, researchers seek clarity on the neurodevelopmental effects of oxytocin during childbirth.

By Laura Dattaro
17 May 2023 | 4 min read
Illustration of hybrid objects: part light bulb, part lab vial, some in blue and some in red to signify null and replicated results.

Null and Noteworthy: Reader response; cerebrospinal fluid; connectivity subgroups

In this edition of Null and Noteworthy, researchers upend early interventions and diagnostic boundaries.

By Laura Dattaro
18 April 2023 | 4 min read
Computer-generated image of mountains against a black background.

Detecting a signal amid noise in autism early-intervention research

Studies of behavioral treatments for autism are complex and can easily be misunderstood. Here we provide some guidance.

By Isabel Smith, Kate Tsiplova, Wendy Ungar
28 March 2023 | 5 min read
Illustration of hybrid objects: part light bulb, part lab vial, some in blue and some in red to signify null and replicated results.

Null and Noteworthy: Registered reports; motor measurements; viral DNA

In this edition of Null and Noteworthy, Spectrum talks with a Nature editor about the journal’s move to publish more null results.

By Laura Dattaro
16 March 2023 | 4 min read

Subscribe to get the Null and Noteworthy newsletter directly in your inbox.

Explore more from The Transmitter

Composite image of a brain probe, a test tube and a brain scan.

Why the 21st-century neuroscientist needs to be neuroethically engaged

Technological advances in decoding brain activity and in growing human brain cells raise new ethical issues. Here is a framework to help researchers navigate them.

By Karen Rommelfanger
12 May 2025 | 6 min read
Two slides feature human brains, with a third slide featuring the silhouette of a brain.

Exclusive: Recruitment issues jeopardize ambitious plan for human brain atlas

A lack of six new brain donors may stop the project from meeting its goal to pair molecular and cellular data with the functional organization of the cortex.

By Calli McMurray
9 May 2025 | 6 min read
Fred Volkmar, in a blue shirt, in front of wall of framed certificates in his office, wearing a blue shirt.

How pragmatism and passion drive Fred Volkmar—even after retirement

Whether looking back at his career highlights or forward to his latest projects, the psychiatrist is committed to supporting autistic people at every age.

By Claudia Wallis
8 May 2025 | 9 min read