Organoids
RNA drug corrects calcium signaling in chimeric model of Timothy syndrome
The drug, tested in rats that have human neurons, could enter clinical testing as early as next year, researchers say.
RNA drug corrects calcium signaling in chimeric model of Timothy syndrome
Microglial overreaction to atypical neurons may drive autism
In mice and organoids lacking a neuronal protein, microglia prune synapses to excess.
Microglial overreaction to atypical neurons may drive autism
On a bold mission to re-engineer brain parts
A European consortium is on a quest to restore typical brain activity in people with epilepsy, using a mash-up of custom organoids, microelectronics and artificial intelligence.
On a bold mission to re-engineer brain parts
Raising the bar for stem cell research: Q&A with Jack Mosher
New quality benchmarks for basic research involving stem cells promise to improve rigor and reproducibility, says Mosher, who helped develop the standards.
Raising the bar for stem cell research: Q&A with Jack Mosher
Method pinpoints cell-specific effects of autism-linked mutations
The approach, which combines CRISPR with single-cell analyses of organoids, suggests that intermediate progenitor cells are especially vulnerable to mutations associated with autism.
Method pinpoints cell-specific effects of autism-linked mutations
Genetic background sways effects of autism-linked mutation
Experiments offer clues to why certain mutations are associated with autism in some people and not others.
Genetic background sways effects of autism-linked mutation
Grafted organoids reveal how microglia adapt to shifting brain environments
The chimeric mouse model could provide a more realistic way to study microglia’s roles in brain conditions such as autism.
Grafted organoids reveal how microglia adapt to shifting brain environments
Immune molecule alters cellular makeup of human brain organoids
The changes may help explain the link between maternal infection and autism, though more research is needed.
Immune molecule alters cellular makeup of human brain organoids
‘Splice-switching’ strategy boosts SYNGAP1 expression
The approach improves the function of SYNGAP1-deficient neurons in vitro, but whether it will work in people remains unclear.
‘Splice-switching’ strategy boosts SYNGAP1 expression
Calming neurons to quell seizures: Q&A with Gabriele Lignani and Dimitri Kullmann
A new gene therapy approach for epilepsy tamps down neural activity on demand.
Calming neurons to quell seizures: Q&A with Gabriele Lignani and Dimitri Kullmann
Explore more from The Transmitter
Robots boost data consistency in rodent studies reliant on mechanical, optogenetic stimulation
Two new devices take experimenter variation out of the equation, the lead investigators say.
Robots boost data consistency in rodent studies reliant on mechanical, optogenetic stimulation
Two new devices take experimenter variation out of the equation, the lead investigators say.
Spina bifida; MDMA effects in a mouse model of autism; maternal autoantibodies
Here is a roundup of autism-related news and research spotted around the web for the week of 13 May.
Spina bifida; MDMA effects in a mouse model of autism; maternal autoantibodies
Here is a roundup of autism-related news and research spotted around the web for the week of 13 May.
Autism research is becoming more diverse but not yet more global
Hosting the International Society for Autism Research annual meeting—which starts tomorrow—in Australia takes a step in that direction, making it easier for researchers, clinicians and advocates from the Western Pacific Region to participate.
Autism research is becoming more diverse but not yet more global
Hosting the International Society for Autism Research annual meeting—which starts tomorrow—in Australia takes a step in that direction, making it easier for researchers, clinicians and advocates from the Western Pacific Region to participate.