SFN 2009

Mounting evidence links language pathway to autism

A pathway involved in language development is increasingly proving to be important in autism, suggest a series of new studies on cellular and behavioral aspects of the disorder.

By Virginia Hughes
26 October 2009 | 8 min read

Enriched environment improves symptoms of Rett

Giving mouse models of Rett syndrome access to toys, wheels and contact with other mice rescues motor skill and other deficits characteristic of the disorder, according to results presented in a poster session Wednesday at the Society for Neuroscience meeting in Chicago.

By Kelly Rae Chi
23 October 2009 | 3 min read

Gene on chromosome 22 leads to autism mouse model

Mice lacking a gene located in the chromosomal region 22q13 — which has been linked to autism — have motor learning and social deficits reminiscent of the disorder, according to unpublished findings presented in a poster session yesterday at the Society for Neuroscience meeting in Chicago.

By Kelly Rae Chi
22 October 2009 | 3 min read

Antibodies to fetal proteins trigger autism features

Antibodies directed against the fetal brain are present in some mothers of children with autism, confirming previous findings and suggesting that the antibodies could be used as a marker for the disorder, according to unpublished research presented yesterday at the Society for Neuroscience meeting in Chicago.

By Kelly Rae Chi
21 October 2009 | 3 min read

Fragile X mice marked by immature synapses

Young mice that mimic fragile X syndrome have immature and unstable dendritic spines, the neuronal branches that receive signals from other cells, according to unpublished research presented Tuesday at the Society for Neuroscience meeting in Chicago.

By Virginia Hughes
21 October 2009 | 2 min read

Postmortem study hints at two types of autism

The brains of people with autism show high levels of inflammation compared with controls, suggests a study of postmortem brain tissue from 11 individuals with autism, presented at a poster session Monday at the Society for Neuroscience meeting in Chicago.

By Virginia Hughes
21 October 2009 | 4 min read

MeCP2 loss ups inhibitory signaling

Selectively disrupting an autism-related gene in cultured human neurons causes a dramatic imbalance of excitation and inhibition in cell signaling, according to unpublished results presented today at the Society for Neuroscience meeting in Chicago.

By Kelly Rae Chi
21 October 2009 | 2 min read

Neuroligin mutation triggers oxidative stress

Deleting a neuronal protein associated with autism causes oxidative stress — characterized by an excess of free radicals — which has been linked to diseases such as diabetes and Alzheimer’s, according to new research in worms. The results were presented yesterday at a poster session at the Society for Neuroscience meeting in Chicago.

By Kelly Rae Chi
20 October 2009 | 2 min read

Lack of corpus callosum linked to autistic features

People born without the large bundle of nerve fibers that bridges the brain's hemispheres have trouble identifying fearful faces, and don't look preferentially at others' eyes to perform this task, according to research presented Sunday at the Society for Neuroscience meeting in Chicago.

By Virginia Hughes
20 October 2009 | 3 min read

Video: NIH director bemoans ‘lack of trust’ in autism field

On Saturday, a top government official resigned from the Interagency Autism Coordination Committee, the body of scientists and advocates that's responsible for guiding all autism research funded by the U.S. National Institutes of Health. Institute director Francis Collins responds.

By Virginia Hughes
20 October 2009 | 2 min read

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