Simons Simplex Collection
Recent articles
Four autism subtypes map onto distinct genes, traits
An analysis of more than 5,000 autistic children and their siblings underscores the idea that autism can be understood as multiple conditions with distinct trajectories.
Four autism subtypes map onto distinct genes, traits
An analysis of more than 5,000 autistic children and their siblings underscores the idea that autism can be understood as multiple conditions with distinct trajectories.
Untangling biological threads from autism’s phenotypic patchwork reveals four core subtypes
People belonging to the same subtype share genetic variants, behaviors and often co-occurring diagnoses, according to a new preprint.
Untangling biological threads from autism’s phenotypic patchwork reveals four core subtypes
People belonging to the same subtype share genetic variants, behaviors and often co-occurring diagnoses, according to a new preprint.
Genome structure could be key factor in some forms of autism
Variants in DNA stretches that do not code for proteins may alter the genome’s 3D architecture, influencing the expression of distant genes linked to autism.
Genome structure could be key factor in some forms of autism
Variants in DNA stretches that do not code for proteins may alter the genome’s 3D architecture, influencing the expression of distant genes linked to autism.
Some who lack autism diagnosis carry variants tied to the condition
The variants are associated with slight differences in measures of intelligence, income and employment, but the relationship may not be causal.
Some who lack autism diagnosis carry variants tied to the condition
The variants are associated with slight differences in measures of intelligence, income and employment, but the relationship may not be causal.
Null and Noteworthy: Modified MRI; father findings
This month’s newsletter tackles null findings from an attempted replication of a “revolutionary” MRI approach and an analysis of family genetics.
Null and Noteworthy: Modified MRI; father findings
This month’s newsletter tackles null findings from an attempted replication of a “revolutionary” MRI approach and an analysis of family genetics.
X-chromosome variants help explain autism’s sex bias
The rare variants are also linked to ADHD and Tourette syndrome, two other conditions that disproportionately affect boys and men.
X-chromosome variants help explain autism’s sex bias
The rare variants are also linked to ADHD and Tourette syndrome, two other conditions that disproportionately affect boys and men.
Scans of sundry variant types uncover autism-linked genes
Troves of sequencing data reveal genes tied to autism through different variant types, providing a more complete picture of the condition’s genetic roots and new clues to its heterogeneity.
Scans of sundry variant types uncover autism-linked genes
Troves of sequencing data reveal genes tied to autism through different variant types, providing a more complete picture of the condition’s genetic roots and new clues to its heterogeneity.
Mutations disrupting chromatin interactions contribute to autism
The mutations occur spontaneously in noncoding stretches of DNA that control gene expression.
Mutations disrupting chromatin interactions contribute to autism
The mutations occur spontaneously in noncoding stretches of DNA that control gene expression.
The final frontier: Autism geneticists take on the noncoding genome
The vast stretches of DNA that don't code for proteins could fill key knowledge gaps about autism genetics. But making sense of it all won't be easy.
The final frontier: Autism geneticists take on the noncoding genome
The vast stretches of DNA that don't code for proteins could fill key knowledge gaps about autism genetics. But making sense of it all won't be easy.
Common inherited variants tied to autism show sex bias in families
Siblings of autistic females are more likely to have autism than siblings of autistic males are, and mothers of autistic children carry more common, autism-linked variants than fathers do.
Common inherited variants tied to autism show sex bias in families
Siblings of autistic females are more likely to have autism than siblings of autistic males are, and mothers of autistic children carry more common, autism-linked variants than fathers do.
Explore more from The Transmitter
Lipids enter brain mapping limelight
Two new studies, including the first whole-brain lipid atlas in mice, uncover unforeseen complexity and influence during pregnancy and aging.
Lipids enter brain mapping limelight
Two new studies, including the first whole-brain lipid atlas in mice, uncover unforeseen complexity and influence during pregnancy and aging.
Behavioral phenomics in zebrafish; and more
Here is a roundup of autism-related news and research spotted around the web for the week of 26 October.
Behavioral phenomics in zebrafish; and more
Here is a roundup of autism-related news and research spotted around the web for the week of 26 October.
Neuroscience gave AI its start. What happens now?
David Sussillo maps the two fields' divergent paths, and where they might still meet.
Neuroscience gave AI its start. What happens now?
David Sussillo maps the two fields' divergent paths, and where they might still meet.