Single-cell sequencing

Research illustration groups genes by their effects on brain cell types.

Giant analysis reveals how autism-linked genes affect brain cell types

Genes that predispose people to autism account for a large portion of the neuronal and glial cell changes seen in those with the condition.

By Charles Q. Choi
20 June 2024 | 5 min read
A research image of autism-linked genes.

Autism-linked perturbations converge on cell skeleton and RNA-binding proteins

The findings solidify the idea that autism-linked mutations affect brain activity by way of several key shared mechanisms.

By Giorgia Guglielmi
29 February 2024 | 4 min read
Research image of various types of cells.
Cell types Microphone

Vast diversity of human brain cell types revealed in trove of new datasets

The collection offers a glimpse into differences in cell composition — across people and brain regions — that may shape neural function.

By Angie Voyles Askham
12 October 2023 | 6 min listen
lllustration of the junction between two nerve cells.
Spectrum Microphone

Multi-omics study captures CNTNAP2’s far-ranging effects

The in-depth approach shows mutations in the autism-linked gene disrupt neuronal growth and communication, as well as mitochondrial gene expression.

By Charles Q. Choi
8 December 2022 | 4 min read
Pink geometric brain against a blue background.
Spectrum Microphone

Autism brain signature most pronounced in sensory areas

An analysis of 11 cortical regions shows anterior-to-posterior shifts in gene expression linked to autism.

By Niko McCarty
2 November 2022 | 6 min read

Glial cells star in autism-linked gene expression analysis

Many genes linked to autism are switched on in the brain's glia, cells that help neurons develop and synapses form.

By Lauren Schenkman
15 December 2021 | 4 min read

New tool maps cell types in lab-grown blobs of brain tissue

The software compares gene expression in cells derived from organoids with a reference atlas of the developing mouse brain.

By Giorgia Guglielmi
29 July 2021 | 3 min read
single celled zygote seen as a colorful cluster of dots, next to a four cell embryo, visualized in the same way.

Intact-cell sequencing lays bare new view of genome structure

The technique enables researchers to sequence the DNA of an intact cell, providing a unique view of the genome’s organization inside the nucleus.

By Chloe Williams
22 April 2021 | 4 min read
Spectrum Microphone

Atlas maps distinct cell types during earliest stages of brain development

A new atlas profiles gene activity early on during development in the human fetal brain.

By Laura Dattaro
1 April 2021 | 3 min read
A digital rendering of a green neuron on black

Brain activity jump-starts autism-linked genes in human neurons

Some neurons activate autism-linked genes when they fire, according to a new study.

By Grace Huckins
5 March 2021 | 5 min read

Explore more from The Transmitter

Brain organoid size matches intensity of social problems in autistic people

Overgrown organoids could point to mechanisms underlying profound autism.

By Holly Barker
18 July 2024 | 5 min read

Persistent protein pairing enables memories to last

The complex of two memory proteins, rather than the individual molecules acting independently, underlie month-long memories in mice, a new study suggests.

By Elissa Welle
17 July 2024 | 5 min read
A digitally distorted image of a file folder against a blue gradient background.

Data access changes to UK Biobank stir unease in neuroscientists

“I feel a little bit in limbo,” says neuroscientist Stephanie Noble, who has paused a study using Biobank data after the repository shifted from a data download to a cloud-only access model.

By Calli McMurray
16 July 2024 | 7 min read