Organoids

Recent articles

Research image of organoids derived from stem cell lines from people with intellectual disability, polymicroglia or microcephaly, alongside a control organoid.

New organoid atlas unveils four neurodevelopmental signatures

The comprehensive resource details data on microcephaly, polymicrogyria, epilepsy and intellectual disability from 352 people.

By Diana Kwon
17 December 2025 | 4 min read
Brain organoid.

What is the future of organoid and assembloid regulation?

Four experts weigh in on how to establish ethical guardrails for research on the 3D neuron clusters as these models become ever more complex.

By Claudia López Lloreda
10 December 2025 | 7 min read
Concentric circles.

What are the most transformative neuroscience tools and technologies developed in the past five years?

Artificial intelligence and deep-learning methods featured prominently in the survey responses, followed by genetic tools to control circuits, advanced neuroimaging, transcriptomics and various approaches to record brain activity and behavior.

By The Transmitter
15 November 2025 | 14 min read
Colorful drawing of a human brain.

‘Neuroethics: The Implications of Mapping and Changing the Brain,’ an excerpt

In his new book, published today, philosopher Walter Glannon examines the ethics of six areas of neuroscience. In Chapter 4, a portion of which appears below, he tackles the ethical considerations of using brain organoids in research.

By Walter Glannon
11 November 2025 | 7 min read
Research image of microglia in organoids.

Microglia nurture young interneurons

The immune cells secrete a growth factor that “sets the supply of GABAergic interneurons in the developing brain.”

By Lauren Schenkman
28 August 2025 | 3 min read
Researcher holds a mouse perched on a glass cylinder.

NIH proposal sows concerns over future of animal research, unnecessary costs

The new NIH policy calls for greater incorporation of new approach methodologies in all future Notices of Funding Opportunities related to animal model systems.

By Claudia López Lloreda
15 July 2025 | 5 min read
Composite image of a brain probe, a test tube and a brain scan.

Why the 21st-century neuroscientist needs to be neuroethically engaged

Technological advances in decoding brain activity and in growing human brain cells raise new ethical issues. Here is a framework to help researchers navigate them.

By Karen Rommelfanger
12 May 2025 | 6 min read
Research image of human cortical neurons xenotransplanted into a mouse brain for months.

In vivo veritas: Xenotransplantation can help us study the development and function of human neurons in a living brain

Transplanted cells offer insight into human-specific properties, such as a lengthy cortical development and sensitivity to neurodevelopmental and neurodegenerative disease.

By Pierre Vanderhaeghen
7 April 2025 | 7 min read
Research image of an assembloid.

Organoids and assembloids offer a new window into human brain

These sophisticated 3D cultures reveal previously inaccessible stages of human brain development and enable the systematic study of disease genes.

By Sergiu P. Pasca
31 March 2025 | 6 min read
Composite of brain imaging techniques.

Thanks to new technologies, neuroscientists have more direct access to the human brain than ever before

Model systems continue to offer us tremendous insight, but it’s time for basic researchers to train their sights on the human brain. If I were starting my career today, I would focus on human neurobiology.

By Joshua R. Sanes
17 March 2025 | 7 min read

Explore more from The Transmitter

Books.

The Transmitter’s most-read neuroscience book excerpts of 2025

Books by Nachum Ulanovsky, Nicole Rust, and Andrew Iwaniuk and Georg Striedter made the list of some of the year's most engaging neuroscience titles.

By The Transmitter
24 December 2025 | 2 min read
Nachum Ulanovsky sits against a black background with one bat in his hands and another with its wings spread above his head.

Neuroscience’s leaders, legacies and rising stars of 2025

Here are seven stories from the past year about some of the field’s most engaging figures.

By The Transmitter
24 December 2025 | 2 min read
Stamp over a sheet of paper.

The Transmitter’s top news articles of 2025

Check out some of our most-read stories, covering neuroscience funding and policy changes in the United States, and methodological issues in high-profile neuroscience papers.

By The Transmitter
24 December 2025 | 3 min read

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