Signaling imbalance
Recent articles
Microglia nurture young interneurons
The immune cells secrete a growth factor that “sets the supply of GABAergic interneurons in the developing brain.”
Microglia nurture young interneurons
The immune cells secrete a growth factor that “sets the supply of GABAergic interneurons in the developing brain.”
Synaptic anomalies in autistic people support imbalance hypothesis
Increased excitatory and decreased inhibitory synapses in the prefrontal cortex of autistic people suggest broader impacts on brain function and connectivity.
Synaptic anomalies in autistic people support imbalance hypothesis
Increased excitatory and decreased inhibitory synapses in the prefrontal cortex of autistic people suggest broader impacts on brain function and connectivity.
Some social issues in DYRK1A model mice stem from faulty inhibitory circuits
Alterations in inhibitory circuits and difficulties in social recognition characterize mice missing one copy of DYRK1A, a gene linked to autism.
Some social issues in DYRK1A model mice stem from faulty inhibitory circuits
Alterations in inhibitory circuits and difficulties in social recognition characterize mice missing one copy of DYRK1A, a gene linked to autism.
Head size parts autism into two major subtypes
An imbalance in the number of excitatory neurons in early brain development may account for the difference.
Head size parts autism into two major subtypes
An imbalance in the number of excitatory neurons in early brain development may account for the difference.
Skewed signaling in striatum may spawn repetitive behaviors
Synaptic changes in the brain region could drive a core trait of fragile X syndrome, a new mouse study suggests.
Skewed signaling in striatum may spawn repetitive behaviors
Synaptic changes in the brain region could drive a core trait of fragile X syndrome, a new mouse study suggests.
Neuronal deafness to stress may add to protein surplus in fragile X
A protective pathway that pauses protein synthesis is muted in a mouse model of fragile X syndrome, according to a new study.
Neuronal deafness to stress may add to protein surplus in fragile X
A protective pathway that pauses protein synthesis is muted in a mouse model of fragile X syndrome, according to a new study.
Trials of arbaclofen for autism yield mixed results
Autistic children taking the drug showed improvements in some behaviors but not in their social skills.
Trials of arbaclofen for autism yield mixed results
Autistic children taking the drug showed improvements in some behaviors but not in their social skills.
Cannabis compound rebalances signaling to quell seizures in mice
Cannabidiol (CBD) blocks the action of a molecule that drives an overexcitability feedback loop in a rodent model of epilepsy.
Cannabis compound rebalances signaling to quell seizures in mice
Cannabidiol (CBD) blocks the action of a molecule that drives an overexcitability feedback loop in a rodent model of epilepsy.
Unconventional optogenetics technique spurs long-lasting changes in neuronal activity
Conventional optogenetic manipulations to excite or inhibit neurons stop when the light switches off. A new approach makes the changes last.
Unconventional optogenetics technique spurs long-lasting changes in neuronal activity
Conventional optogenetic manipulations to excite or inhibit neurons stop when the light switches off. A new approach makes the changes last.
Of mice and human interneurons: Q&A with Moritz Helmstaedter
People’s brains have a larger network of inhibitory interneurons than mouse brains do, according to a new study. Changes to that network could contribute to autism or other conditions, says lead investigator Moritz Helmstaedter.
Of mice and human interneurons: Q&A with Moritz Helmstaedter
People’s brains have a larger network of inhibitory interneurons than mouse brains do, according to a new study. Changes to that network could contribute to autism or other conditions, says lead investigator Moritz Helmstaedter.
Explore more from The Transmitter
To persist, memories surf molecular waves from thalamus to cortex
During the later stages of learning, the mouse brain progressively activates transcriptional regulators that drive memory consolidation.
To persist, memories surf molecular waves from thalamus to cortex
During the later stages of learning, the mouse brain progressively activates transcriptional regulators that drive memory consolidation.
Sex hormone boosts female rats’ sensitivity to unexpected rewards
During the high-estradiol stages of their estrus cycle, female rats learn faster than they do during other stages—and than male rats overall—thanks to a boost in their dopaminergic response to reward, a new study suggests.
Sex hormone boosts female rats’ sensitivity to unexpected rewards
During the high-estradiol stages of their estrus cycle, female rats learn faster than they do during other stages—and than male rats overall—thanks to a boost in their dopaminergic response to reward, a new study suggests.
SHANK3 deficiency and behavior in mice; and more
Here is a roundup of autism-related news and research spotted around the web for the week of 24 November.
SHANK3 deficiency and behavior in mice; and more
Here is a roundup of autism-related news and research spotted around the web for the week of 24 November.