Statistics

Recent articles

Research images shows areas of cortex that differed across scans of variable quality.

Poor image quality introduces systematic bias into large neuroimaging datasets

Analyses that include low-quality MRI data underestimate cortical thickness and overestimate cortical surface area, according to new findings from the Adolescent Brain Cognitive Development (ABCD) Study.

By Natalia Mesa
31 July 2025 | 7 min listen
Overlapping speech bubbles.

Memory study sparks debate over statistical methods

Critics of a 2024 Nature paper suggest the authors failed to address the risk of false-positive findings. The authors argue more rigorous methods can result in missed leads.

By Katie Moisse
2 July 2025 | 5 min read
An opaque cube is repeated multiple times to create the appearance of overlapping cubes.

Sounding the alarm on pseudoreplication: Q&A with Constantinos Eleftheriou and Peter Kind

Most studies of neurological disorders in mice erroneously treat multiple samples from a single animal as independent replicates, according to a new analysis. But scientists and journals can take steps to curb this practice.

By Lauren Schenkman
12 June 2025 | 6 min read
A curly line connects two pencils that are hovering over overlapping speech bubbles.

Say what? The Transmitter’s top quotes of 2024

“We’ve cured mouse-heimer’s thousands of times...”—find out who said this to a Transmitter reporter, and read our other favorite quotes from the past year.

By The Transmitter
23 December 2024 | 2 min read
Illustration of a single digitally rendered figure wandering a fragmented and distorted virtual environment.

Nonsense correlations and how to avoid them

This statistical error is common in systems neuroscience. Fortunately, straightforward methods can help you prevent it.

By Kenneth Harris
12 August 2024 | 6 min listen

Explore more from The Transmitter

Stack of papers.

Exclusive: The 23 studies the FDA based its expanded leucovorin label on

The studies include 46 people, mostly toddlers, who have cerebral folate deficiency due to variants in a folate transporter.

By Claudia López Lloreda
2 October 2025 | 6 min read
Hand holding a rubber stamp above a stack of papers.

Autism researchers ‘pleasantly surprised’ by list of NIH data project grantees, despite initial concerns

An atypical funding mechanism, truncated application timeline and opaque review process had generated concern over the quality of projects that would be selected for the Autism Data Science Initiative.

By Calli McMurray
2 October 2025 | 10 min read
Richard Frye.

Exclusive: Who is Richard Frye, the neurologist who researches and advocates for leucovorin as an autism treatment?

Frye has led two placebo-controlled trials of the folate supplement in autistic people; the first was suspended by regulators, and the other has yet to be published.

By Brendan Borrell
1 October 2025 | 11 min read

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