CHD8
Recent articles
Sequencing study spotlights tight web of genes tied to autism
The findings, shared in a preprint, help to illuminate how a large and heterogeneous group of genes could be involved in autism.
Sequencing study spotlights tight web of genes tied to autism
The findings, shared in a preprint, help to illuminate how a large and heterogeneous group of genes could be involved in autism.
CRISPR gives autism-linked genes a boost, rescues functioning
A modified form of the gene-editing tool increases the expression of CHD8 and SCN2A, showing potential for autism therapies.
CRISPR gives autism-linked genes a boost, rescues functioning
A modified form of the gene-editing tool increases the expression of CHD8 and SCN2A, showing potential for autism therapies.
Autism-related genes converge on microglia and dopamine in zebrafish
The findings add to the growing evidence that genes with disparate functions can play similar roles in brain development.
Autism-related genes converge on microglia and dopamine in zebrafish
The findings add to the growing evidence that genes with disparate functions can play similar roles in brain development.
Chromatin remodeling tied to altered splicing in autism model
Exposing neurons to valproic acid, a well-known environmental risk factor for autism, disrupts their ability to generate different proteins from the same gene.
Chromatin remodeling tied to altered splicing in autism model
Exposing neurons to valproic acid, a well-known environmental risk factor for autism, disrupts their ability to generate different proteins from the same gene.
CHD8 mutation in 33 mouse strains yields range of traits
The findings put genetic background forward to help explain autism’s heterogeneity.
CHD8 mutation in 33 mouse strains yields range of traits
The findings put genetic background forward to help explain autism’s heterogeneity.
Flexible genomic architecture undergoes major redesigns during cerebellum development
A new atlas reveals how the structural shake-ups within a cell’s genome differ by cell type and brain region over time.
Flexible genomic architecture undergoes major redesigns during cerebellum development
A new atlas reveals how the structural shake-ups within a cell’s genome differ by cell type and brain region over time.
Community Newsletter: Autism gene lists, genetic diversity in mouse models, an autism biomarker
This week, we’re bringing you some labors of love: a thread lamenting the autism field’s focus on gene lists, a study introducing genetic diversity in mouse models, and long-awaited results from a biomarker study.
Community Newsletter: Autism gene lists, genetic diversity in mouse models, an autism biomarker
This week, we’re bringing you some labors of love: a thread lamenting the autism field’s focus on gene lists, a study introducing genetic diversity in mouse models, and long-awaited results from a biomarker study.
‘Double duty’ autism-linked genes upend conventional characterizations
What these genes do and how they affect autism depends on when in development they’re studied, despite what classic ‘gene ontology’ analyses say.
‘Double duty’ autism-linked genes upend conventional characterizations
What these genes do and how they affect autism depends on when in development they’re studied, despite what classic ‘gene ontology’ analyses say.
Heart anomalies abound in mouse models of autism
Of nine genetic models examined in a new study, all had some incidence of cardiac abnormalities. But the problems varied widely depending on the affected genes.
Heart anomalies abound in mouse models of autism
Of nine genetic models examined in a new study, all had some incidence of cardiac abnormalities. But the problems varied widely depending on the affected genes.
Organoids show how mutations in top autism gene may lead to brain overgrowth in people
The loss of CHD8, a top autism gene, speeds up the production of certain neurons and leads to overgrowth in spheres of cultured brain cells.
Organoids show how mutations in top autism gene may lead to brain overgrowth in people
The loss of CHD8, a top autism gene, speeds up the production of certain neurons and leads to overgrowth in spheres of cultured brain cells.
Explore more from The Transmitter
ABCD Study omits gender-identity data from latest release
The removal counteracts the goals of the longitudinal study by “pretending that some aspects of adolescent brain development don’t exist,” says sex differences researcher Nicola Grissom.
ABCD Study omits gender-identity data from latest release
The removal counteracts the goals of the longitudinal study by “pretending that some aspects of adolescent brain development don’t exist,” says sex differences researcher Nicola Grissom.
Neuropeptides reprogram social roles in leafcutter ants
The mechanisms that control the labor roles of ants may also be conserved in naked mole rats, a new study shows.
Neuropeptides reprogram social roles in leafcutter ants
The mechanisms that control the labor roles of ants may also be conserved in naked mole rats, a new study shows.
Perspectives from the field: Opinions in autism research
This collection of Spectrum articles from the past 12 months highlights expert perspectives on autism’s heritability and its link to biological sex, the value of transdiagnostic frameworks, and the field’s future, among other topics.
Perspectives from the field: Opinions in autism research
This collection of Spectrum articles from the past 12 months highlights expert perspectives on autism’s heritability and its link to biological sex, the value of transdiagnostic frameworks, and the field’s future, among other topics.