Brian O’Roak uses genomic approaches to unlock the genetic basis of neurodevelopmental disorders such as autism and intellectual disability.
Brian O’Roak
Associate professor of molecular and medical genetics
Oregon Health and Science University
From this contributor
How I learned to stop worrying and love preprints
Preprints are gaining traction in biology, but some researchers have lingering concerns. Should they?
Burning debate: What’s the best way to nab real autism genes?
How to best use a large volume of data to discover new genetic risk factors for autism is a matter of intense debate, particularly in light of historical challenges.
Burning debate: What’s the best way to nab real autism genes?
By
Brian O’Roak
27 June 2017 | 9 min read
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Eighteen teams analyzed the same neurophysiology dataset—and got wildly different answers
The “Brainhack” hackathon revealed that disagreement in neuroscience runs deeper than most researchers suspect—even in electrophysiology, a field that prides itself on hard data.
Eighteen teams analyzed the same neurophysiology dataset—and got wildly different answers
The “Brainhack” hackathon revealed that disagreement in neuroscience runs deeper than most researchers suspect—even in electrophysiology, a field that prides itself on hard data.
By
Gaëlle Chapuis, Mattia Chini
1 June 2026 | 7 min read
‘Unbelievably beautiful’ evidence extends Nobel Prize-winning model of vision
Orientation tuning—the ability to distinguish a horizontal line from a vertical one or something in between—originates in the visual cortex, according to new mouse synapse imaging experiments.
‘Unbelievably beautiful’ evidence extends Nobel Prize-winning model of vision
Orientation tuning—the ability to distinguish a horizontal line from a vertical one or something in between—originates in the visual cortex, according to new mouse synapse imaging experiments.
By
Claudia López Lloreda
29 May 2026 | 5 min read
Bringing basic biology back to INSAR
As the International Society for Autism Research has grown over the past two decades, basic science has become less central, Christine Wu Nordahl says. This year, she and other meeting organizers aimed to change that.
Bringing basic biology back to INSAR
As the International Society for Autism Research has grown over the past two decades, basic science has become less central, Christine Wu Nordahl says. This year, she and other meeting organizers aimed to change that.
By
Diana Kwon
28 May 2026 | 6 min read