Brian O’Roak

Associate professor of molecular and medical genetics
Oregon Health and Science University

Brian O’Roak uses genomic approaches to unlock the genetic basis of neurodevelopmental disorders such as autism and intellectual disability.

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Research image of expression of MEIS2 in PV interneurons.

Loss of interneuron plasticity may be shared hallmark of neurodevelopmental conditions

Restoring an experience-dependent interneuron plasticity gene in adulthood improves memory and cuts seizures in CNTNAP2 knockout mice, a new study shows.

By Claudia López Lloreda
12 August 2026 | 5 min read
Structural MRI scans of people with Alzheimer’s disease and depression.

Neuropsychiatric MRI brain signatures fail reproducibility test

Small neuroimaging studies are unlikely to capture consistent anatomical changes related to conditions such as autism, schizophrenia and mood disorders, according to a new “wake-up call” study.

By Holly Barker
12 August 2026 | 5 min read
Research image of astrocytes.

Three models, three routes to altered auditory processing, and more

Here is a roundup of autism-related news and research spotted around the web for the week of 10 August.

By Jill Adams
11 August 2026 | 2 min read