Sarkis Mazmanian
Professor of microbiology
California Institute of Technology
From this contributor
Remembering Paul Patterson (1944-2014)
Paul H. Patterson, a transformative figure in autism research, died on 25 June. His groundbreaking discoveries advanced novel paradigms in neuroscience and immunology, and introduced concepts that will continue to be developed by researchers worldwide.
The case for using ‘prebiotics’
Prebiotics — nutrients that promote the growth of some beneficial gut bacteria — can influence brain chemistry and behavior. New findings suggest prebiotics as treatments for people with neurological disorders, say Sarkis Mazmanian and Gil Sharon.
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Worms help untangle brain structure/function mystery
The synaptic connectome of most animals bears little resemblance to functional brain maps, but it can still predict neuronal activity, according to two preprints that tackle the puzzle in C. elegans.

Worms help untangle brain structure/function mystery
The synaptic connectome of most animals bears little resemblance to functional brain maps, but it can still predict neuronal activity, according to two preprints that tackle the puzzle in C. elegans.
Microglia nurture young interneurons
The immune cells secrete a growth factor that “sets the supply of GABAergic interneurons in the developing brain.”

Microglia nurture young interneurons
The immune cells secrete a growth factor that “sets the supply of GABAergic interneurons in the developing brain.”
Xaq Pitkow shares his principles for studying cognition in our imperfect brains and bodies
Pitkow discusses how evolution's messy constraints shape optimal brain algorithms, from Bayesian inference to ecological affordances.
Xaq Pitkow shares his principles for studying cognition in our imperfect brains and bodies
Pitkow discusses how evolution's messy constraints shape optimal brain algorithms, from Bayesian inference to ecological affordances.