Excitatory signaling
Recent articles
Diverse autism genes derail common developmental pathways
Multiple genetic mouse models initially show delayed cortical development, but the animals’ molecular trajectories diverge within weeks after birth, a new study finds.
Diverse autism genes derail common developmental pathways
Multiple genetic mouse models initially show delayed cortical development, but the animals’ molecular trajectories diverge within weeks after birth, a new study finds.
Neuroscience needs single-synapse studies
Studying individual synapses has the potential to help neuroscientists develop new theories, better understand brain disorders and reevaluate 70 years of work on synaptic transmission plasticity.
Neuroscience needs single-synapse studies
Studying individual synapses has the potential to help neuroscientists develop new theories, better understand brain disorders and reevaluate 70 years of work on synaptic transmission plasticity.
Gene replacement therapy normalizes some traits in SYNGAP1 model mice
The first published virus-based gene therapy for SYNGAP1 deletion yields benefits despite the gene’s long length and complexity.
Gene replacement therapy normalizes some traits in SYNGAP1 model mice
The first published virus-based gene therapy for SYNGAP1 deletion yields benefits despite the gene’s long length and complexity.
Ramping up cortical activity in early life sparks autism-like behaviors in mice
The findings add fuel to the long-running debate over how an imbalance in excitatory and inhibitory signaling contributes to the autism.
Ramping up cortical activity in early life sparks autism-like behaviors in mice
The findings add fuel to the long-running debate over how an imbalance in excitatory and inhibitory signaling contributes to the autism.
Sensory gatekeeper drives seizures, autism-like behaviors in mouse model
The new work, in mice missing the autism-linked gene CNTNAP2, suggests a mechanism to help explain the overlap between epilepsy and autism.
Sensory gatekeeper drives seizures, autism-like behaviors in mouse model
The new work, in mice missing the autism-linked gene CNTNAP2, suggests a mechanism to help explain the overlap between epilepsy and autism.
‘Understudied secret’ in brain dampens nicotine drive in mice
The interpeduncular nucleus produces an aversion to nicotine, even at low doses, and helps moderate how rewarding mice find the drug.
‘Understudied secret’ in brain dampens nicotine drive in mice
The interpeduncular nucleus produces an aversion to nicotine, even at low doses, and helps moderate how rewarding mice find the drug.
Inhibitory cells work in concert to orchestrate neuronal activity in mouse brain
A cubic millimeter of brain tissue, meticulously sectioned, stained and scrutinized over the past seven years, reveals in stunning detail the role of inhibitory interneurons in brain structure and function.
Inhibitory cells work in concert to orchestrate neuronal activity in mouse brain
A cubic millimeter of brain tissue, meticulously sectioned, stained and scrutinized over the past seven years, reveals in stunning detail the role of inhibitory interneurons in brain structure and function.
Bespoke photometry system captures variety of dopamine signals in mice
The tool tracks the excitation of an engineered protein that senses dopamine’s absolute levels, including fast and slow fluctuations in real time, and offers new insights into how the signals change across the brain.
Bespoke photometry system captures variety of dopamine signals in mice
The tool tracks the excitation of an engineered protein that senses dopamine’s absolute levels, including fast and slow fluctuations in real time, and offers new insights into how the signals change across the brain.
What are recurrent networks doing in the brain?
The cortex is filled with excitatory local synapses, but we know little about their role in brain function. New experimental tools, along with ideas from artificial intelligence, are poised to change that.
What are recurrent networks doing in the brain?
The cortex is filled with excitatory local synapses, but we know little about their role in brain function. New experimental tools, along with ideas from artificial intelligence, are poised to change that.
Newfound gene network controls long-range connections between emotional, cognitive brain areas
The finding could help unravel gene regulatory networks and explain how genetic and environmental factors interact in neurodevelopmental conditions.
Newfound gene network controls long-range connections between emotional, cognitive brain areas
The finding could help unravel gene regulatory networks and explain how genetic and environmental factors interact in neurodevelopmental conditions.
Explore more from The Transmitter
Measuring plastic in the brain: Improving, but incomplete
Meanwhile, researchers are publishing papers without “sufficient quality control,” says analytical chemist Dušan Materić.
Measuring plastic in the brain: Improving, but incomplete
Meanwhile, researchers are publishing papers without “sufficient quality control,” says analytical chemist Dušan Materić.
Incredible shrinking grant deadlines at the BRAIN Initiative
“A month is crazy,” says one former recipient, referring to a new funding opportunity’s timeline.
Incredible shrinking grant deadlines at the BRAIN Initiative
“A month is crazy,” says one former recipient, referring to a new funding opportunity’s timeline.
Sylvia Fogel, reshaping U.S. autism research strategy
In a wide-ranging and provocative interview, the chair of the federal Interagency Autism Coordinating Committee shares her views on vaccines, regression, neuroimmune conditions and more.
Sylvia Fogel, reshaping U.S. autism research strategy
In a wide-ranging and provocative interview, the chair of the federal Interagency Autism Coordinating Committee shares her views on vaccines, regression, neuroimmune conditions and more.