Profound autism

Recent articles

A clinician holds a clipboard while someone else sits on a couch.

Expediting clinical trials for profound autism: Q&A with Matthew State

Aligning Research to Impact Autism, a new initiative funded by the Sergey Brin Family Foundation, wants to bring basic science discoveries to the clinic faster.

By Lauren Schenkman
24 April 2025 | 8 min read
Black-and-white research image of brain organoids.

Brain organoid size matches intensity of social problems in autistic people

Overgrown organoids could point to mechanisms underlying profound autism.

By Holly Barker
18 July 2024 | 5 min read
Portrait of Matthew Siegel sitting on a staircase.

Pinning down ‘profound autism’ for reliable research: Q&A with Matthew Siegel

A clear and actionable definition for the term could enhance research and improve care, Matthew Siegel says.

By Katie Moisse
13 June 2024 | 7 min read

Building bridges: Collaboration across the autism community

An autistic person and the mother of an autistic child explore partnership in the autism community.

By Samantha Easter, Amy S.F. Lutz
24 October 2023 | 10 min read
Photograph of a woman in a dim room looking out her window.

Weaponized heterogeneity only harms the most vulnerable autistic people

Focusing on aspects of autistic experience that we all share may lead more quickly to our shared goal of improved outcomes for all autistic people.

By Mary Doherty
17 April 2023 | 8 min read
Lone figure treads a central path that splits into two, surrounded on both sides by an uncertain, shifting landscape in murky colors.

It’s time to embrace ‘profound autism’

My experience at the Autism-Europe International Congress — and as a parent of a child with profound autism — makes me more convinced than ever that we need to bifurcate the diagnosis of ‘autism spectrum disorder’ and add a new diagnosis of ‘profound autism’ to better serve this vulnerable population.

By Alison Singer
27 October 2022 | 8 min read
An abstract "funding mechanism" featuring dollar bills alongside tubes, beakers and wires

New program offers $35K grants to study ‘profound autism’

People who have ‘profound autism’ — those with severe intellectual disability, limited communication abilities or both — tend to be excluded from research. The Autism Science Foundation seeks to change that.

By Peter Hess
18 July 2022 | 5 min read
Illustration shows yellow landscape with blue sections and a lot of trains on paths with kids on the trains, going different directions.

Mapping the futures of autistic children

Researchers can roughly project what autistic children's lives will look like years down the road. But how good is their crystal ball — and what are its benefits?

By Elizabeth Svoboda
14 July 2021 | 18 min read
MRIs show changes over time

Big brain may mark subtype of autism

Autistic boys with large brains in early childhood still have large brains in adolescence, challenging the long-standing idea that brain enlargement in autism is temporary.

By Laura Dattaro
27 November 2020 | 6 min read
Adolescent has cheek swabbed

Autism, intellectual disability linked to levels of fragile X protein

People with particularly low levels of FMRP, the protein lacking in those with fragile X syndrome, are more likely to also have autism and severe intellectual disability.

By Laura Dattaro
26 October 2020 | 5 min read

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Research image of lesion network mapping.

‘Overdue’ debate unfurls over neuroimaging method

After a January paper questioned the validity of an approach called lesion network mapping, its users are pressure testing their results.

By Angie Voyles Askham
17 April 2026 | 8 min read
Research image of zebrafish brain activity.

Nearly 400 compounds affect behaviors tied to autism-linked genes in zebrafish

Estropipate, paclitaxel and levocarnitine altered behaviors tied to SCN2A and DYRK1A variants specifically, a new open-source platform revealed.

By Charles Q. Choi
16 April 2026 | 4 min read
NINDS building.

What neuroscientists want from a new NINDS director

The search is underway for the next director of the U.S. National Institute of Neurological Disorders and Stroke, who will face a range of challenges, neuroscientists say, but will also have an “immense opportunity to do good things.”

By Helena Kudiabor
15 April 2026 | 4 min read