Theoretical neuroscience

Recent articles

Speech bubbles and images of a brain overlaid on a globe.

A community-designed experiment tests open questions in predictive processing

More than 50 scientists came together to identify the key missing data needed to rigorously test theoretical models.

By Jérôme Lecoq
12 November 2025 | 6 min read
Illustration of a series of floating pools of water overflowing into each other.

The missing half of the neurodynamical systems theory

Bifurcations—an underexplored concept in neuroscience—can help explain how small differences in neural circuits give rise to entirely novel functions.

By Xiao-Jing Wang
27 October 2025 | 8 min read

Ann Kennedy explains the theoretical neuroscience of survival behaviors

The Scripps neuroscientist calls for a broader theoretical neuroscience approach in her area of research, which focuses on how the subcortex bridges life and cognition.

By Paul Middlebrooks
24 September 2025 | 1 min read

Xaq Pitkow shares his principles for studying cognition in our imperfect brains and bodies

Pitkow discusses how evolution's messy constraints shape optimal brain algorithms, from Bayesian inference to ecological affordances.

By Paul Middlebrooks
27 August 2025 | 1 min read
Illustration of a brain made up of ones and zeros.

Long-standing theoretical neuroscience fellowship program loses financial support

Funding from the Swartz and Sloan Foundations helped bring physicists and mathematicians into neuroscience for more than 30 years.

By Calli McMurray
26 August 2025 | 5 min read
A series of colored rectangles in a cosmos-like black space.

The challenge of defining a neural population

Our current approach is largely arbitrary. We need new methods for grouping cells, ideally by their dynamics.

By Mark Humphries
11 August 2025 | 8 min read

Xiao-Jing Wang outlines the future of theoretical neuroscience

Wang discusses why he decided the time was right for a new theoretical neuroscience textbook and how bifurcation is a key missing concept in neuroscience explanations.

By Paul Middlebrooks
2 July 2025 | 112 min listen
A blue 3D cube made of interlacing smooth, round tubes.

Thinking about thinking: AI offers theoretical insights into human memory

We need a new conceptual framework for understanding cognitive functions—particularly how globally distributed brain states are formed and maintained for hours.

By Terrence Sejnowski
5 May 2025 | 7 min read
Two scientists walk along interlocking rings.

Breaking the barrier between theorists and experimentalists

Many neuroscience students are steeped in an experiment-first style of thinking that leads to “random walk science.” Let’s not forget how theory can guide experiments toward deeper insights.

By Samuel Gershman
24 February 2025 | 6 min read
Futuristic illustration of overlapping circles and bright dots.

Future watch: What should neuroscience prioritize during the next 10 to 20 years?

For The Transmitter’s first annual book, five contributing editors reflect on what subfields demand greater focus in the near future—from dynamical systems and computation to technologies for studying the human brain.

By The Transmitter
23 December 2024 | 4 min read

Explore more from The Transmitter

Autism scientists push back on CDC’s inaccurate vaccine claims

The CDC website now falsely suggests that autism-vaccine research is still an open question, prompting distrust among researchers—some of whom anticipate “more unreliable statements coming from the junta that took over” the agency.

By The Transmitter
21 November 2025 | 6 min read

Gene replacement therapy normalizes some traits in SYNGAP1 model mice

The first published virus-based gene therapy for SYNGAP1 deletion yields benefits despite the gene’s long length and complexity.

By Charles Q. Choi
20 November 2025 | 5 min read

Does AI understand what it produces? Henk de Regt explores how we might assess understanding in machines and humans

Building on his philosophy of how scientists understand what they work on, de Regt is extending his approach to test understanding in machines.

By Paul Middlebrooks
19 November 2025 | 1 min read

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