Theories of autism
The signaling imbalance theory of autism, explained
The signaling imbalance theory holds that the brains of autistic people are hyper-excitable because of either excess neuronal activity or weak brakes on that activity.
![](https://www.thetransmitter.org/wp-content/uploads/2019/05/20190501-E-I-imbalance844.jpg)
The signaling imbalance theory of autism, explained
The signaling imbalance theory holds that the brains of autistic people are hyper-excitable because of either excess neuronal activity or weak brakes on that activity.
The female protective effect, explained
One of the leading theories of autism posits that girls and women are biologically protected from the condition.
![](https://www.thetransmitter.org/wp-content/uploads/2019/04/20190424_Female-protective_1120.jpg)
The female protective effect, explained
One of the leading theories of autism posits that girls and women are biologically protected from the condition.
The extreme male brain, explained
The ‘extreme male brain’ theory suggests that autism is an exaggeration of systematic sex differences in ways of thinking.
![Illustration of a strong man holding up a oversized brain](https://www.thetransmitter.org/wp-content/uploads/2019/05/20190501-ExtremeMale-844.jpg)
The extreme male brain, explained
The ‘extreme male brain’ theory suggests that autism is an exaggeration of systematic sex differences in ways of thinking.
Serotonin’s link to autism, explained
Serotonin, the brain chemical best known for its link to depression, may also be involved in autism.
![Illustration of red figures on a big blue brain are serotonin signaling](https://www.thetransmitter.org/wp-content/uploads/2019/05/20190501-Serotonin-844.jpg)
Serotonin’s link to autism, explained
Serotonin, the brain chemical best known for its link to depression, may also be involved in autism.
The multiple hits theory of autism, explained
Researchers are studying how a combination of genetic ‘hits’ may contribute to autism’s diversity.
![A DNA helix showing common and rare variants](https://www.thetransmitter.org/wp-content/uploads/2019/05/20190501-multiple-hits844.jpg)
The multiple hits theory of autism, explained
Researchers are studying how a combination of genetic ‘hits’ may contribute to autism’s diversity.
The predictive coding theory of autism, explained
In autism, a person's brain may not form accurate predictions of imminent experiences, or even if it does, sensory input may override those predictions.
![Illustration shows the world is distorted through a point of view pair of glasses](https://www.thetransmitter.org/wp-content/uploads/2018/05/20190501-Predictive844.jpg)
The predictive coding theory of autism, explained
In autism, a person's brain may not form accurate predictions of imminent experiences, or even if it does, sensory input may override those predictions.
The connectivity theory of autism, explained
A growing body of evidence suggests that autism involves atypical communication between brain regions, but how and where in the brain this plays out is unclear.
![overlapping network of connections in the brain](https://www.thetransmitter.org/wp-content/uploads/2019/05/20190501-ContradictoryConnect_844.jpg)
The connectivity theory of autism, explained
A growing body of evidence suggests that autism involves atypical communication between brain regions, but how and where in the brain this plays out is unclear.
Explore more from The Transmitter
New connectomes fly beyond the brain
Researchers are mapping the neurons in Drosophila’s ventral nerve cord, where the central nervous system meets the rest of the body.
![Research image of neurons in the fly’s ventral nerve cord.](https://www.thetransmitter.org/wp-content/uploads/2024/07/lede-motormodules-1200-1024x692.webp)
New connectomes fly beyond the brain
Researchers are mapping the neurons in Drosophila’s ventral nerve cord, where the central nervous system meets the rest of the body.
Building an autism research registry: Q&A with Tony Charman
A purpose-built database of participants who have shared genomic and behavioral data could give clinical trials a boost, Charman says.
![Illustration of researchers talking to laypeople amidst strands of DNA.](https://www.thetransmitter.org/wp-content/uploads/2024/07/1200_Charman-1024x687.webp)
Building an autism research registry: Q&A with Tony Charman
A purpose-built database of participants who have shared genomic and behavioral data could give clinical trials a boost, Charman says.
Cerebellar circuit may convert expected pain relief into real thing
The newly identified circuit taps into the brain’s opioid system to provide a top-down form of pain relief.
![](https://www.thetransmitter.org/wp-content/uploads/2024/07/paincircuit-1200-1024x692.webp)
Cerebellar circuit may convert expected pain relief into real thing
The newly identified circuit taps into the brain’s opioid system to provide a top-down form of pain relief.