Timothy syndrome

Research image of antisense oligonucleotides.

RNA drug corrects calcium signaling in chimeric model of Timothy syndrome

The drug, tested in rats that have human neurons, could enter clinical testing as early as next year, researchers say.

By Katie Moisse
24 April 2024 | 5 min read
A transplanted human organoid labeled with a fluorescent protein in a section of the rat brain.
Spectrum Microphone

Human cortical organoids forge functional circuits in rat brains

The transplanted cells integrate into living animals’ neural circuitry and influence behavior.

By Peter Hess
12 October 2022 | 4 min read

Mini-brains bare tortuous trek of cells in Timothy syndrome

A new technique for building a ‘brain in a dish’ reveals how neurons move to their proper places during fetal development.

By Sarah DeWeerdt
23 June 2017 | 3 min read

Mighty element plays major part in autism

Probing the function of a protein in a calcium signaling pathway may lead to a diagnostic test for autism and a path toward treatments.

By John Jay Gargus, Galina Schmunk
18 April 2017 | 5 min read

Rising Star: Sergiu Pasca, scientist at play

Sergiu Pasca was among the first to model autism with neurons from affected individuals, a feat that could reveal the biochemical roots of some forms of autism.

By Sarah DeWeerdt
19 February 2015 | 9 min read

Rho family of enzymes at crossroads of autism

A number of autism risk factors converge on one cellular pathway: abnormal remodeling of the cell's structural systems through the signaling protein Rho, says SFARI’s associate director for research, Alan Packer.

By Alan Packer
12 March 2013 | 10 min read
Illustration of pyramidal neurons against a deep blue background.

Molecular mechanisms: Timothy syndrome neurons defective

Neurons from people with Timothy syndrome, and from mouse and rat models of the disorder, have defects in the growth of their branches, according to a study published 13 January in Nature Neuroscience.

By Veronique Greenwood
12 March 2013 | 2 min read

Exploring enigmatic links between mitochondria and autism

Mitochondrial deficits may account for the range of symptoms and neurological deficits seen in autism and explain why it preferentially affects boys, says Douglas Wallace.

By Douglas Wallace
8 January 2013 | 9 min read

Allen Institute aims to mass-produce stem cells

The nonprofit Allen Institute for Brain Science in Seattle plans to make neurons from stem cells derived from people with a number of different disorders. The resource, described 25 September at a conference in New York, will be available to all scientists.

By Emily Singer
5 October 2012 | 5 min read

Rodent roundup

SAGE Labs has announced a new partnership with the autism science and advocacy organization Autism Speaks to fund the creation of three new rat models of autism.

By Virginia Hughes
10 August 2012 | 2 min read

Explore more from The Transmitter

A digitally distorted image of a file folder against a blue gradient background.

Data access changes to UK Biobank stir unease in neuroscientists

“I feel a little bit in limbo,” says neuroscientist Stephanie Noble, who has paused a study using Biobank data after the repository shifted from a data download to a cloud-only access model.

By Calli McMurray
16 July 2024 | 7 min read
Illustration of an open journal featuring lines of text and small illustrations of eyes and mouths.

Bumetanide; sex-biased gene expression; racial and ethnic disparities

Here is a roundup of autism-related news and research spotted around the web for the week of 15 July.

By Jill Adams
16 July 2024 | 1 min read
Illustration of a scientist attempting to wrangle many forms of data at once: a pile of charts and graphs threatens to knock them off of their feet as they attempt to prop it up.

Neuroscience graduate students deserve comprehensive data-literacy education

Despite growing requirements around how to handle and share data, formal training is lacking.

By Letisha R. Wyatt
15 July 2024 | 6 min read